Meta-analysiscited by the Tayebat archiveabstract only checked A-INS-17 standard review

Weight gain with insulin

Increase of body weight during the first year of intensive insulin treatment in type 2 diabetes: systematic review and meta-analysis.

Overview

Pontiroli AE et al.. Diabetes Obes Metab 2011 · PMID 21645195 · DOI 10.1111/j.1463-1326.2011.01433.x

The more intensive the insulin treatment, the more weight people gain in the first year.

Does the study support the specific claim? Partly · Methodological quality: moderate

Study explained simply

What did the researchers want to find out?: Weight increase in first year of insulin treatment and predictors
How was the study done?: Systematic review and meta-analysis of 46 RCTs
How many people, animals or samples were studied?: 46 RCTs; Type 2 diabetes starting/intensifying insulin
What was actually found?: Weight gain related to intensity and regimen.
How large was the observed effect?: not reported in abstract
What do the results mean in everyday life?: Weight gain is a real insulin side effect.
What are the study's limitations?: Effect sizes not in abstract; Heterogeneous trials
What does it say about Elawady's specific claim?: Supports weight-gain kernel of C-INS-01.
Do the results apply to Germany and Europe?: International.
What can explicitly not be concluded from this study?: That insulin causes obesity in general.

Weight increase in first year of insulin treatment and predictors

Study design: Meta-analysis – Systematic review and meta-analysis of 46 RCTs
Population: Type 2 diabetes starting/intensifying insulin
Country: International
Period: Published RCTs (dates not given)
Sample size: 46 RCTs
Inclusion and exclusion criteria: As described in the abstract; details not available in abstract.

Results: Weight gain associated with treatment intensity (target FBG, dose, final HbA1c, hypoglycaemia). Less with basal than twice-daily or prandial; less with detemir than NPH; glargine vs NPH no difference.
Absolute risks: not reported
Authors' conclusion: Weight increase during the first year of insulin is associated with treatment intensity and depends on regimen.

Qualitative conclusions only in abstract.

Supports weight-gain kernel of C-INS-01.

International.

Reliable on weight gain.

Multidimensional assessment
Multidimensional assessment
Authenticity of the source	verified
Methodological quality	moderate
Risk of bias	some concerns
Precision of results	not applicable
Directness	direct
Reproducibility	replicated
Consistency with the overall evidence	consistent
Regional transferability	high
Adequacy of the interpretation (by the archive)	correctly reported

None beyond those stated.

Note: according to the archive, the studies were compiled by the archive operators. Whether Dr. Elawady himself cited this study is not established.

What the archive says about the study: Listed in the archive bibliography for 'insulin-injections' without its own interpretation; used as general support for the claim that insulin intensification harms.
A. What was actually studied?: Weight increase in first year of insulin treatment and predictors
B. What did the authors find?: Weight gain related to intensity and regimen.
C. What conclusions do the authors themselves draw?: Weight increase during the first year of insulin is associated with treatment intensity and depends on regimen.
D. What does the archive derive from it?: Supports insulin-induced weight gain.
E. Is this derivation scientifically justified?: Justified.
Adequacy of the interpretation (by the archive): correctly reported