Cohort studycited by the Tayebat archiveabstract only checked★ key study A-ORG-14 in-depth review

Ovary removal before menopause and dementia

Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause.

Overview

Rocca WA et al.. Neurology 2007 · PMID 17761551 · DOI 10.1212/01.wnl.0000276984.19542.e6

Women who had ovaries removed before menopause had 46% higher risk of cognitive impairment or dementia later.

Does the study support the specific claim? Yes · Methodological quality: moderate

Study explained simply

What did the researchers want to find out?: Dementia
How was the study done?: Cohort
How many people, animals or samples were studied?: 2961
What was actually found?: Higher risk
How large was the observed effect?: HR 1.46
What do the results mean in everyday life?: Possible brain cost of early ovary removal
What are the study's limitations?: Observational
What does it say about Elawady's specific claim?: Supports association
Do the results apply to Germany and Europe?: Applicable
What can explicitly not be concluded from this study?: Causation

Authors: Rocca WA, Bower JH, Maraganore DM, Ahlskog JE, Grossardt BR, de Andrade M, Melton LJ
Journal: Neurology
Year: 2007
Identifier: PMID 17761551 DOI 10.1212/01.wnl.0000276984.19542.e6
Verification: verified (PMID in archive was wrong, corrected) – PubMed E-utilities efetch, 2026-10-25
Retracted: no
Corrections: none
Extent checked: abstract only
Conflicts of interest and funding: COI: not stated in record | Grants: NIAMS NIH HHS, NINDS NIH HHS

Premenopausal oophorectomy and cognitive impairment/dementia

Study design: Cohort study – Historical cohort (Mayo Clinic Cohort Study of Oophorectomy and Aging)
Population: Olmsted County women, oophorectomy before menopause, non-cancer indication
Country: USA
Period: 1950-1987
Sample size: 813 unilateral, 676 bilateral, 1472 referents

Results: HR 1.46 (1.13-1.90) adjusted; risk increased with younger age at oophorectomy (trend P<0.0001); similar regardless of indication and for unilateral/bilateral.
Absolute risks: not reported
Authors' conclusion: Premenopausal oophorectomy associated with increased risk of cognitive impairment or dementia; age-dependent.

Supports C-ORG-11.

Applicable.

Correctly cited.

Multidimensional assessment
Multidimensional assessment
Authenticity of the source	verified (PMID in archive was wrong, corrected)
Methodological quality	moderate
Risk of bias	some concerns
Precision of results	moderate
Directness	direct
Reproducibility	partly replicated
Consistency with the overall evidence	consistent
Regional transferability	moderate
Adequacy of the interpretation (by the archive)	correctly reported

Note: according to the archive, the studies were compiled by the archive operators. Whether Dr. Elawady himself cited this study is not established.

What the archive says about the study: Premenopausal oophorectomy raised cognitive impairment or dementia 1.46-fold, risk rising the younger the age at surgery.
A. What was actually studied?: Oophorectomy and dementia
B. What did the authors find?: HR 1.46; age gradient
C. What conclusions do the authors themselves draw?: Associated; age-dependent
D. What does the archive derive from it?: Used to support hormonal-network protection of the brain.
E. Is this derivation scientifically justified?: Correctly reported (association). Archive PMID was wrong (pointed to a Parkinson study); corrected in register.
Adequacy of the interpretation (by the archive): correctly reported