Meta-analysisindependent cross-checkabstract checked I-EGG-110 standard review

More than one egg a day not linked to heart disease

Association Between Egg Consumption and Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis.

Overview

Krittanawong C et al.. Am J Med 2021 · PMID 32653422 · DOI 10.1016/j.amjmed.2020.05.046

HR 0.99 (0.93-1.06) for cardiovascular events in 1.4 million people.

Does the study support the specific claim? No · Methodological quality: moderate

Study explained simply

What did the researchers want to find out?: Pool cohort studies on eggs and CVD.
How was the study done?: Meta-analysis.
How many people, animals or samples were studied?: 23 studies, 1.4 million people.
What was actually found?: No higher CVD risk.
How large was the observed effect?: HR 0.99.
What do the results mean in everyday life?: Eating eggs regularly was not linked to more heart disease.
What are the study's limitations?: Observational; overlapping studies.
What does it say about Elawady's specific claim?: Contradicts it.
Do the results apply to Germany and Europe?: Moderate.
What can explicitly not be concluded from this study?: It cannot prove eggs protect the heart.

Authors: Krittanawong C et al.
Journal: Am J Med
Year: 2021
Identifier: PMID 32653422 DOI 10.1016/j.amjmed.2020.05.046
Verification: verified – PubMed efetch 2026-10-26; Crossref works API 2026-10-26
Retracted: no
Corrections: none
Extent checked: abstract only
Conflicts of interest and funding: not stated in abstract

Is egg consumption associated with cardiovascular disease events?

Study design: Meta-analysis – Systematic review and random-effects meta-analysis of prospective studies
Population: 23 prospective studies, 1,415,839 individuals
Country: Multinational
Period: Search to January 2020
Sample size: 1,415,839 participants; 157,324 CVD events
Inclusion and exclusion criteria: not detailed in abstract

Results: More than 1 egg/day vs no or 1 egg/day: CVD HR 0.99 (95% CI 0.93-1.06; I2 72.1%); coronary artery disease HR 0.89 (0.86-0.93; I2 0%).
Absolute risks: not reported
Authors' conclusion: Higher egg consumption (>1/day) was not associated with increased CVD risk and was associated with lower CAD risk.

CVD CI log-symmetric; the inverse CAD finding with I2 0% is surprising and should not be over-read (possible confounding).

Contradicts the claim that eggs raise CVD risk at intakes above one per day.

Zhao 2022 (I-EGG-109).

Mixed regions.

Supports no association; overlaps with other syntheses, so not independent confirmation.

Multidimensional assessment
Multidimensional assessment
Authenticity of the source	verified
Methodological quality	moderate
Risk of bias	some concerns
Precision of results	high
Directness	direct
Reproducibility	partly replicated
Consistency with the overall evidence	mixed
Regional transferability	moderate
Adequacy of the interpretation (by the archive)	not applicable

Dose-response not reported in abstract.