Cohort studyindependent cross-checkabstract checked I-EGG-111 standard review

Iranian study: eggs not linked to heart disease

Egg consumption and risk of cardiovascular events among Iranians: results from Isfahan Cohort Study (ICS).

Overview

Mohammadifard N et al.. Eur J Clin Nutr 2022 · PMID 35347253 · DOI 10.1038/s41430-022-01118-1

Eating eggs 3+ times a week was not linked to heart attacks, strokes or CVD over 12 years.

Does the study support the specific claim? No · Methodological quality: moderate

Study explained simply

What did the researchers want to find out?: Study eggs and CVD in Iran.
How was the study done?: Cohort of 6,504 adults.
How many people, animals or samples were studied?: 6,504.
What was actually found?: No significant associations.
How large was the observed effect?: CVD HR 1.05 (0.79-1.40).
What do the results mean in everyday life?: In a Middle Eastern population, regular egg eating was not linked to heart disease.
What are the study's limitations?: Imprecise estimates.
What does it say about Elawady's specific claim?: Contradicts it regionally.
Do the results apply to Germany and Europe?: Moderate.
What can explicitly not be concluded from this study?: It cannot exclude a small effect.

Authors: Mohammadifard N et al.
Journal: Eur J Clin Nutr
Year: 2022
Identifier: PMID 35347253 DOI 10.1038/s41430-022-01118-1
Verification: verified – PubMed efetch 2026-10-26; Crossref works API 2026-10-26
Retracted: no
Corrections: none
Extent checked: abstract only
Conflicts of interest and funding: not stated in abstract

Is egg consumption associated with cardiovascular events in an Iranian population?

Study design: Cohort study – Prospective cohort, median 12-year follow-up
Population: 6,504 adults aged >=35 years without CVD at baseline, Isfahan, Iran
Country: Iran
Period: 12-year follow-up
Sample size: 6,504
Inclusion and exclusion criteria: not detailed in abstract

Exposure / intervention: >=3 eggs/week (validated FFQ)
Comparator: <1 egg/week
Endpoints: MI, ischaemic heart disease, stroke, CVD, CVD mortality
Statistical methods: Cox frailty models adjusted for age, sex, education, residency, smoking, activity, family history, metabolic syndrome, aspirin, BMI, Global Dietary Index

Results: >=3 vs <1 per week: MI HR 1.44 (0.86-2.41); ischaemic heart disease HR 1.26 (0.80-1.99); stroke HR 0.79 (0.46-1.38); CVD HR 1.05 (0.79-1.40); all non-significant.
Absolute risks: not reported
Authors' conclusion: Higher egg consumption was not associated with increased risk of MI, ischaemic heart disease, stroke or CVD among Iranians.

Wide CIs (MI 0.86-2.41) cannot exclude moderate increases; null finding is imprecise.

Closest regional (Middle East) cohort evidence: no association between moderate egg intake and CVD.

Imprecise; point estimate for MI above 1.

Regional relevance for Egypt (similar dietary context in the Middle East) is higher than for US cohorts.

Regionally relevant, imprecise null result.

Multidimensional assessment
Multidimensional assessment
Authenticity of the source	verified
Methodological quality	moderate
Risk of bias	some concerns
Precision of results	low
Directness	direct
Reproducibility	partly replicated
Consistency with the overall evidence	consistent
Regional transferability	high
Adequacy of the interpretation (by the archive)	not applicable

No Egyptian cohort on eggs and CVD found.