Systematic reviewindependent cross-checkabstract checked I-EGG-117 standard review

Eggs after prostate cancer diagnosis: mixed findings

Postdiagnostic Red Meat, Poultry, and Egg Intake and Risk of Prostate Cancer Progression and Mortality: A Systematic Review.

Overview

Sandhu S et al.. J Urol 2026 · PMID 42607142 · DOI 10.1097/JU.0000000000005263

Most studies found no link at around 2.5-3 eggs per week; one found a link at about 5.5 per week.

Does the study support the specific claim? Unclear · Methodological quality: moderate

Original publication

Plain-language summary

Study explained simply
What did the researchers want to find out?

Review diet after diagnosis and prostate cancer outcomes.

How was the study done?

Systematic review.

How many people, animals or samples were studied?

6 cohorts.

What was actually found?

Inconsistent evidence for eggs.

How large was the observed effect?

Not pooled.

What do the results mean in everyday life?

The link between eggs and deadly prostate cancer remains unproven.

What are the study's limitations?

Few studies.

What does it say about Elawady's specific claim?

Does not confirm the 81% figure.

Do the results apply to Germany and Europe?

Moderate.

What can explicitly not be concluded from this study?

It cannot exclude a risk at very high intakes.

Scientific in-depth review

1. Full reference

Authors
Sandhu S et al.
Journal
J Urol
Year
2026
Identifier
PMID 42607142 DOI 10.1097/JU.0000000000005263
Verification
verified – PubMed efetch 2026-10-26; Crossref works API 2026-10-26
Retracted
no
Corrections
none
Extent checked
abstract only
Conflicts of interest and funding

not stated in abstract

2. Research question

Is postdiagnostic intake of red meat, poultry and eggs associated with prostate cancer progression and mortality?

3. Study design and population

Study design
Systematic review – Systematic review of prospective cohorts (no meta-analysis)
Population

Men with prostate cancer in 6 cohorts (>10,000 men)

Country

Multinational

Period

Search to 17 July 2025

Sample size

>10,000 men; 6 cohorts

Inclusion and exclusion criteria

not detailed in abstract

4. Methods and endpoints

Exposure / intervention

Postdiagnostic egg (and meat/poultry) intake

Comparator

Lower intake

Endpoints

Progression, prostate cancer-specific mortality, all-cause mortality

Statistical methods

Narrative synthesis with risk-of-bias assessment

5. Actual results

Results

Egg evidence inconsistent: a positive association with progression in 1 study with very high intake in the top category (~5.5 servings/week); no associations in 4 studies with top categories of >=2.5-3 servings/week; 1 of 2 studies showed a positive association with all-cause mortality.

Absolute risks

not reported

Authors' conclusion

Evidence is limited and inconsistent; progression risk may be specific to higher egg intake (>3-5 servings/week).

6. Strengths

  • Recent; risk-of-bias assessment

7. Weaknesses

  • Few studies; no pooling
  • Postdiagnostic population differs from the claim (incidence of lethal cancer)

8. Risk of bias

Orienting tool
ROBIS
Type of assessment
simplified assessment (abstract only)
Full formal assessment
no
Overall risk of bias
some concerns
Rationale

Narrative review.

9. Assessment of the statistical interpretation

Not pooled; inconsistent findings.

10. Relevance to the specific claim

Up-to-date synthesis showing that egg-prostate cancer findings are inconsistent; no association at the 2.5-3/week level in most studies.

11. Independent contrary findings

One study with high intake found a positive association.

12. Transferability to Germany and Europe

Mixed.

13. Overall methodological judgement

Supports 'unclear' rather than an established risk.

Multidimensional assessment
Multidimensional assessment
Authenticity of the sourceverified
Methodological qualitymoderate
Risk of biassome concerns
Precision of resultsnot applicable
Directnessindirect
Reproducibilitynot replicated
Consistency with the overall evidenceinconsistent
Regional transferabilitymoderate
Adequacy of the interpretation (by the archive)not applicable

14. Open questions

Dose threshold (>5 eggs/week?).

15. Linked fact checks