Risk assessmentindependent cross-checkabstract checked I-EGG-122 standard review

Iranian supermarket eggs: lead and cadmium below safe limits

Risk assessment of lead and cadmium concentrations in hen's eggs using Monte Carlo simulations.

Overview

Hoseini H et al.. Food Sci Nutr 2023 · PMID 37324917 · DOI 10.1002/fsn3.3268

Lead and cadmium in eggs from 17 brands were below permitted levels; no health risk was estimated.

Does the study support the specific claim? No · Methodological quality: moderate

Original publication

Plain-language summary

Study explained simply
What did the researchers want to find out?

Assess metal risk from eggs.

How was the study done?

Lab analysis plus Monte Carlo risk model.

How many people, animals or samples were studied?

42 eggs, 17 brands.

What was actually found?

Levels below limits; no risk.

How large was the observed effect?

THQ < 1.

What do the results mean in everyday life?

Store-bought eggs were not a meaningful source of lead or cadmium.

What are the study's limitations?

Small sample.

What does it say about Elawady's specific claim?

Contradicts it.

Do the results apply to Germany and Europe?

Moderate.

What can explicitly not be concluded from this study?

It cannot speak for polluted local areas.

Scientific in-depth review

1. Full reference

Authors
Hoseini H et al.
Journal
Food Sci Nutr
Year
2023
Identifier
PMID 37324917 DOI 10.1002/fsn3.3268
Verification
verified – PubMed efetch 2026-10-26; Crossref works API 2026-10-26
Retracted
no
Corrections
none
Extent checked
abstract only
Conflicts of interest and funding

No conflicts declared; funding not stated in abstract.

2. Research question

What are Pb and Cd levels in commercial hen eggs in Iran and what risk do they pose?

3. Study design and population

Study design
Risk assessment – Exposure measurement with probabilistic (Monte Carlo) risk assessment
Population

Commercial hen eggs from 17 major brands, Iranian supermarkets

Country

Iran

Period

not stated in abstract

Sample size

42 eggs

Inclusion and exclusion criteria

not detailed in abstract

4. Methods and endpoints

Exposure / intervention

Commercial hen eggs

Comparator

FAO/WHO and Iranian maximum levels; JECFA reference values

Endpoints

Pb, Cd concentrations; EWI, THQ, ILCR

Statistical methods

ICP-MS; Monte Carlo simulation

5. Actual results

Results

Mean Pb 7.16 +/- 0.248 and Cd 2.83 +/- 0.151 ug/kg whole egg, below FAO/WHO and Iranian maximum levels; estimated weekly intake 0.014 (Pb) and 0.007 (Cd) mg/week; THQ < 1; ILCR for Pb < 10^-6.

Absolute risks

not reported

Authors' conclusion

Lead and cadmium levels in all evaluated eggs were suitable for human consumption.

6. Strengths

  • 17 brands
  • Probabilistic exposure modelling

7. Weaknesses

  • Small sample size
  • Single country

8. Risk of bias

Orienting tool
none applicable
Type of assessment
simplified assessment (abstract only)
Full formal assessment
no
Overall risk of bias
some concerns
Rationale

Limited sampling.

9. Assessment of the statistical interpretation

Exposures far below reference values.

10. Relevance to the specific claim

Commercial eggs in a Middle Eastern market had Pb and Cd below limits with no estimated health risk.

11. Independent contrary findings

Pollution hotspots (A-EGG-07).

12. Transferability to Germany and Europe

Regional relevance.

13. Overall methodological judgement

Supports that routine commercial eggs are not a heavy-metal hazard.

Multidimensional assessment
Multidimensional assessment
Authenticity of the sourceverified
Methodological qualitymoderate
Risk of biassome concerns
Precision of resultsmoderate
Directnessdirect
Reproducibilitypartly replicated
Consistency with the overall evidenceconsistent
Regional transferabilitymoderate
Adequacy of the interpretation (by the archive)not applicable

14. Open questions

Egyptian data.

15. Linked fact checks