Cross-sectional studyindependent cross-checkabstract only checked I-LEG-07 standard review
G6PD deficiency in Egyptian oases
Glucose-6-phosphate dehydrogenase deficiency and sulfadimidin acetylation phenotypes in Egyptian oases.
Overview
Hussein L et al.. Biochem Genet 1992 · PMID 1590743 · DOI 10.1007/BF02399702
5.9% of 1,315 men screened in two oases had G6PD deficiency.
Does the study support the specific claim? Partly · Methodological quality: low
Plain-language summary
Study explained simply
- What did the researchers want to find out?
Screen oases
- How was the study done?
Population screening
- How many people, animals or samples were studied?
1,315 males
- What was actually found?
5.9%
- How large was the observed effect?
Not applicable
- What do the results mean in everyday life?
Deficiency is common in parts of Egypt.
- What are the study's limitations?
Regional, old
- What does it say about Elawady's specific claim?
Context
- Do the results apply to Germany and Europe?
Moderate
- What can explicitly not be concluded from this study?
Cannot represent all Egypt.
Scientific in-depth review
1. Full reference
- Authors
- Hussein L et al.
- Journal
- Biochem Genet
- Year
- 1992
- Identifier
- PMID 1590743 DOI 10.1007/BF02399702
- Verification
- verified – PubMed efetch 2026-10-25
- Retracted
- no
- Corrections
- none
- Extent checked
- abstract only
- Conflicts of interest and funding
not stated in abstract
2. Research question
G6PD deficiency frequency in Egyptian oases.
3. Study design and population
- Study design
- Cross-sectional study – Population screening
- Population
Males from two oases
- Country
Egypt
- Period
Not stated
- Sample size
1,315
- Inclusion and exclusion criteria
Males
4. Methods and endpoints
- Exposure / intervention
Not applicable
- Comparator
Not applicable
- Endpoints
G6PD deficiency; acetylation phenotype
- Statistical methods
Descriptive
5. Actual results
- Results
G6PD deficiency incidence 5.9%; 73% rapid acetylators.
- Absolute risks
not reported
- Authors' conclusion
Correlation between high G6PD deficiency and slow acetylation frequency.
6. Strengths
- Population sample
7. Weaknesses
- Oases only; old
8. Risk of bias
- Orienting tool
- none applicable
- Type of assessment
- simplified assessment (abstract only)
- Full formal assessment
- no
- Overall risk of bias
- some concerns
- Rationale
Regional.
9. Assessment of the statistical interpretation
Descriptive.
10. Relevance to the specific claim
Egyptian prevalence context (C-LEG-03).
11. Independent contrary findings
None.
12. Transferability to Germany and Europe
Egypt-specific (oases).
13. Overall methodological judgement
Indicative.
| Multidimensional assessment | |
|---|---|
| Authenticity of the source | verified |
| Methodological quality | low |
| Risk of bias | some concerns |
| Precision of results | moderate |
| Directness | indirect |
| Reproducibility | partly replicated |
| Consistency with the overall evidence | unknown |
| Regional transferability | moderate |
| Adequacy of the interpretation (by the archive) | not applicable |
14. Open questions
National prevalence.