False Certainty of evidence: high provisional C-INS-08

Diabetic ketoacidosis (DKA) does not kill anyone; it should be treated with corticosteroids and complete fasting from food and drink for days, without insulin and without intravenous fluids; giving insulin in this situation is 'the black disaster'.

Safety note: High blood glucose together with ketones (acetone) in urine or blood, especially with nausea, vomiting, abdominal pain, rapid breathing, thirst or drowsiness, can mean diabetic ketoacidosis, a medical emergency. In people taking SGLT2 inhibitors (e.g. dapagliflozin/Forxiga, empagliflozin) ketoacidosis can occur with normal or only mildly raised glucose. Seek emergency care; do not wait or fast it out. Do not stop or reduce insulin on the basis of this claim. In type 1 diabetes and other insulin-deficient states, stopping insulin leads within hours to days to diabetic ketoacidosis, which is life-threatening. Medically accepted position (ADA Standards of Care 2026): insulin treatment is essential for people with type 1 diabetes; people on intensive insulin therapy should not stop basal insulin even when not eating. Any change of diabetes medication should be made together with the treating physician. Corticosteroids and fasting without water are not a treatment for ketoacidosis.
Conclusion: DKA is deadly without treatment; insulin and fluids save lives, cortisone and dry fasting do not.

Original statement

مش عايز محاليل محاليل ايه كورتيكوست لحد ما يفك وصيام اكل وشرب ان بي او لا ايام مش عايز علاج ديكي ايه

verbatim according to source. Translation by the project; the Arabic wording is authoritative.

Translation

Diabetic ketoacidosis (DKA) does not kill anyone; it should be treated with corticosteroids and complete fasting from food and drink for days, without insulin and without intravenous fluids; giving insulin in this situation is 'the black disaster'.

Origin

Source status
Video transcript (own words)
Attribution
Elawady (machine transcript)
Video
الغيبوبات السكرية ؟! (Open source)
Published
30 April 2025
Timestamp
0:49:40 (location in the original video’s automatic YouTube caption track; confirms where the words occur, not who speaks)
Attribution uncertainty
Archive transcript (YouTube CC or AI-generated); no timestamps; 'published' is the date listed by the archive and may be the upload date. Live-stream transcripts can contain viewer comments read aloud; the quoted passage was checked in context to be spoken by Elawady.
Claimed mechanism

Coma in DKA is due to blood pooling in a congested liver/gut; cortisone restores circulation; ketones and glucose are liver products.

Claimed health effect

Denial of DKA as deadly; rejection of insulin and fluids in DKA

Population concerned

People with diabetes in hyperglycaemic crisis

Geographic restriction by Elawady

none found

Diverging source versions

Source status
Video transcript (own words)
Attribution
Elawady (machine transcript)
Video
Dr Diaa Al Awady د ضياء العوضي is live! البروستاتا البنكرياس الكلي الخصيتين ايه وجه الشبه بينهم ؟! (Open source)
Published
29 August 2025
Timestamp
not available (transcript has no timings)
Attribution uncertainty
Archive transcript (YouTube CC or AI-generated); no timestamps; 'published' is the date listed by the archive and may be the upload date. Live-stream transcripts can contain viewer comments read aloud; the quoted passage was checked in context to be spoken by Elawady.
Source status
Video transcript (own words)
Attribution
Elawady (machine transcript)
Video
Dr Diaa Al Awady د ضياء العوضي is live! النسيج البيني التعرق التبول ؟!! (Open source)
Published
15 October 2025
Timestamp
not available (transcript has no timings)
Attribution uncertainty
Archive transcript (YouTube CC or AI-generated); no timestamps; 'published' is the date listed by the archive and may be the upload date. Live-stream transcripts can contain viewer comments read aloud; the quoted passage was checked in context to be spoken by Elawady.

Scientific assessment

False – The statement contradicts the robust evidence.

Certainty of evidence: high – Further research is very unlikely to change the assessment.

1. What was claimed?

DKA is harmless; treatment should be cortisone plus multi-day fasting without food, drink, insulin or fluids.

2. What is demonstrably correct?

Elawady correctly lists three hyperglycaemic emergencies (DKA, hyperosmolar state, lactic acidosis), correctly notes that SGLT2 inhibitors can cause ketoacidosis, sometimes with near-normal glucose (I-ODD-10), and that ketosis occurs in starvation.

3. What is wrong or exaggerated?

DKA is a life-threatening emergency. The 2024 consensus states: 'Insulin therapy is the cornerstone of DKA management and should be started as soon as possible after diagnosis', with isotonic fluids at 500-1,000 mL/h initially and potassium replacement; 'Appropriate treatment has reduced mortality owing to DKA to <1%' (I-INS-07). Without optimal treatment DKA has 'appreciable, although largely preventable, morbidity and mortality' (I-INS-08). In the canagliflozin programme, DKA cases were driven by insulin deficiency (autoimmune diabetes, insulin omission or dose reduction) and acute illness, with glucose above 300 mg/dL, which supports insulin treatment rather than withholding it (A-ODD-10). Patients with DKA are severely dehydrated, so withholding fluids and imposing a dry fast would worsen shock and kidney failure. Glucocorticoids 'may precipitate acute and sustained hyperglycemia by countering insulin action' (I-INS-07). The hypothesis of hepatic/intestinal blood pooling as the cause of DKA coma has no supporting evidence.

4. What remains unclear?

Nothing material.

5. Which studies support it?

None for the treatment claim.

6. Which studies contradict it?

I-INS-07, I-INS-08, I-INS-10, A-ODD-10.

7. What applies to Germany and Europe?

German and European emergency practice follows the same consensus (EASD and JBDS are co-authors of I-INS-07).

8. What is known about Egypt?

DKA is a common cause of emergency admission of children and young adults with diabetes in Egypt and the region; delayed treatment increases mortality. Advice to avoid hospitals and insulin is particularly dangerous where access to care is already delayed.

9. What practical conclusion is appropriate?

Suspected DKA requires immediate emergency medical treatment with insulin, fluids and electrolytes. Corticosteroids and fasting are not treatments for DKA.

Assessment details

Rationale for certainty of evidence

International consensus (ADA/EASD/JBDS/AACE/DTS 2024) based on decades of evidence: insulin is 'the cornerstone of DKA management', with IV fluids and potassium. DKA mortality is <1% only with appropriate treatment. Glucocorticoids raise glucose and can precipitate hyperglycaemic crises. Elawady himself says in the same video that cortisone increases ketones and glucose.

Source quality

Own words, machine transcripts of two separate videos (identical lecture published as live and edited version).

Regional transferability

Universal.

Individual exceptions

None.

Regional scope of the claim
general (biological/medical)
Last reviewed
25 October 2026 provisional

In plain language

Diabetic ketoacidosis happens when the body has far too little insulin: blood sugar and acids rise, and the body loses a lot of water. It is an emergency. Hospitals treat it with fluids through a drip, insulin and salts such as potassium; with this treatment fewer than 1 in 100 adults die. Cortisone raises blood sugar and fasting without water makes dehydration worse, so the advice in this video could be fatal.

Studies on this claim

Studies supporting the claim (0)

No studies in this group.

Studies contradicting or limiting the claim (4)

  • International guideline on diabetic ketoacidosis

    Umpierrez GE et al.. Diabetes Care 2024 · PMID 39052901 · DOI 10.2337/dci24-0032
    Guideline / position statementindependent cross-checkfull text checked★ key study

    Insulin, fluids and potassium are the core treatment; with this, fewer than 1% of adults die.

    Does the study support the specific claim? No · Methodological quality: high · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    Diagnosis and management of DKA and HHS in adults

    How was the study done?

    International consensus report based on systematic examination of literature since 2009 (ADA, EASD, JBDS, AACE, DTS)

    How many people, animals or samples were studied?

    not applicable; Adults with diabetes

    What was actually found?

    Insulin is the cornerstone; glucocorticoids worsen hyperglycaemia.

    How large was the observed effect?

    Mortality <1% with treatment

    What do the results mean in everyday life?

    Ketoacidosis needs hospital treatment with insulin.

    What are the study's limitations?

    Consensus, not trial

    What does it say about Elawady's specific claim?

    Directly contradicts C-INS-08; supports danger in C-FAST-03; contradicts C-INS-07, C-INS-10.

    Do the results apply to Germany and Europe?

    EASD and JBDS (UK) co-authored; directly applicable.

    What can explicitly not be concluded from this study?

    Outcomes of untreated DKA quantitatively.

    Scientific details →

  • Review on diabetic ketoacidosis

    Dhatariya KK et al.. Nat Rev Dis Primers 2020 · PMID 32409703 · DOI 10.1038/s41572-020-0165-1
    Narrative reviewindependent cross-checkfull text checked

    DKA is an emergency that can kill; it is treated with fluids, insulin and salts, and insulin must not be stopped in type 1 diabetes even when not eating.

    Does the study support the specific claim? No · Methodological quality: moderate · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    Epidemiology, pathogenesis, diagnosis and management of DKA

    How was the study done?

    Narrative expert review (Nature Reviews Disease Primers)

    How many people, animals or samples were studied?

    not applicable; Adults and children with diabetes

    What was actually found?

    DKA is diagnosed by high glucose, ketones and acid; it kills <1% when treated in rich countries but up to 26-41% where treatment is lacking; treatment is fluids, insulin and potassium, and insulin must never be stopped in type 1 diabetes even when not eating.

    How large was the observed effect?

    not applicable

    What do the results mean in everyday life?

    DKA is an emergency.

    What are the study's limitations?

    Narrative expert review without systematic methods; one author has research support from insulin makers.

    What does it say about Elawady's specific claim?

    Contradicts C-INS-08, C-INS-02, C-FAST-01, C-FAST-03.

    Do the results apply to Germany and Europe?

    International.

    What can explicitly not be concluded from this study?

    Quantitative estimates.

    Scientific details →

  • ADA guideline 2026: blood sugar goals and emergencies

    American Diabetes Association Professional Practice Committee for Diabetes* . Diabetes Care 2026 · PMID 41358894 · DOI 10.2337/dc26-S006
    Guideline / position statementindependent cross-checkfull text checked★ key study

    Most adults should aim for HbA1c below 7%, avoid low sugar, and measure ketones when at risk.

    Does the study support the specific claim? Partly · Methodological quality: high · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    Glycaemic goals, hypoglycaemia and hyperglycaemic crises

    How was the study done?

    Clinical practice guideline (ADA Standards of Care 2026, Section 6)

    How many people, animals or samples were studied?

    not applicable; People with diabetes

    What was actually found?

    Individual targets; do not stop basal insulin when not eating.

    How large was the observed effect?

    not applicable

    What do the results mean in everyday life?

    Moderate targets and safety rules.

    What are the study's limitations?

    US-centred; Partially read

    What does it say about Elawady's specific claim?

    Supports C-INS-04, C-INS-11; contradicts C-FAST-01, C-FAST-03, C-DIAB-02.

    Do the results apply to Germany and Europe?

    Consistent with EASD guidance.

    What can explicitly not be concluded from this study?

    Not applicable.

    Scientific details →

  • Ketoacidosis with canagliflozin

    Erondu N et al.. Diabetes Care 2015 · PMID 26203064 · DOI 10.2337/dc15-1251
    Othercited by the Tayebat archivefull text checked

    Ketoacidosis was rare (7 per 10,000 patients), often with insulin deficiency or triggers.

    Does the study support the specific claim? Partly · Methodological quality: low · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    Incidence of DKA with canagliflozin

    How was the study done?

    Pooled safety analysis of randomised trials

    How many people, animals or samples were studied?

    17,596; Type 2 diabetes in canagliflozin program

    What was actually found?

    DKA 0.07%.

    How large was the observed effect?

    0.52-0.76 vs 0.24 per 1,000 PY

    What do the results mean in everyday life?

    Rare but real risk.

    What are the study's limitations?

    Analysed and written by manufacturer employees; only 12 cases; based on investigator reports (may miss cases).

    What does it say about Elawady's specific claim?

    Supports C-ODD-02; mixed for C-INS-08.

    Do the results apply to Germany and Europe?

    Multinational/US/UK data; transferable to EU practice.

    What can explicitly not be concluded from this study?

    Precise relative risk; that euglycaemic DKA is common (cases here had high glucose).

    Scientific details →

Studies with mixed or unclear results (0)

No studies in this group.

Regional context

Germany / EU

German and European emergency practice follows the same consensus (EASD and JBDS are co-authors of I-INS-07).

Egypt

DKA is a common cause of emergency admission of children and young adults with diabetes in Egypt and the region; delayed treatment increases mortality. Advice to avoid hospitals and insulin is particularly dangerous where access to care is already delayed.

What applies in my country?

General scientific assessment

False DKA is deadly without treatment; insulin and fluids save lives, cortisone and dry fasting do not.

This statement concerns biological or medical relationships. The scientific assessment above applies regardless of the country; country-specific food data do not change it.

References

  1. Hyperglycemic Crises in Adults With Diabetes: A Consensus Report.. Umpierrez GE et al.. Diabetes Care 2024 · PMID 39052901 · DOI 10.2337/dci24-0032
  2. Diabetic ketoacidosis.. Dhatariya KK et al.. Nat Rev Dis Primers 2020 · PMID 32409703 · DOI 10.1038/s41572-020-0165-1
  3. 6. Glycemic Goals, Hypoglycemia, and Hyperglycemic Crises: Standards of Care in Diabetes-2026.. American Diabetes Association Professional Practice Committee for Diabetes* . Diabetes Care 2026 · PMID 41358894 · DOI 10.2337/dc26-S006
  4. Diabetic Ketoacidosis and Related Events in the Canagliflozin Type 2 Diabetes Clinical Program.. Erondu N et al.. Diabetes Care 2015 · PMID 26203064 · DOI 10.2337/dc15-1251

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