Cohort studycited by the Tayebat archiveabstract only checked A-ABX-08 standard review
Childhood antibiotics and IBD (UK)
Antibiotic exposure and IBD development among children: a population-based cohort study.
Overview
Kronman MP et al.. Pediatrics 2012 · PMID 23008454 · DOI 10.1542/peds.2011-3886
IBD was more common after antianaerobic antibiotics, but absolute rates remained low.
Does the study support the specific claim? Partly · Methodological quality: moderate
Plain-language summary
Study explained simply
- What did the researchers want to find out?
Link.
- How was the study done?
Cohort.
- How many people, animals or samples were studied?
1.07 million.
- What was actually found?
Association.
- How large was the observed effect?
1.52 vs 0.83/10,000 PY.
- What do the results mean in everyday life?
Rare outcome.
- What are the study's limitations?
Confounding.
- What does it say about Elawady's specific claim?
Association.
- Do the results apply to Germany and Europe?
High.
- What can explicitly not be concluded from this study?
Causation.
Scientific in-depth review
1. Full reference
- Authors
- Kronman MP, Zaoutis TE, Haynes K, Feng R, Coffin SE
- Journal
- Pediatrics
- Year
- 2012
- Identifier
- PMID 23008454 DOI 10.1542/peds.2011-3886 · PMC4074626
- Verification
- verified – PubMed E-utilities efetch, 2026-10-25
- Retracted
- no
- Corrections
- none
- Extent checked
- abstract only
- Conflicts of interest and funding
not stated in abstract/record (grants: AHRQ HHS, NCRR NIH HHS, NICHD NIH HHS, NIGMS NIH HHS)
2. Research question
Antianaerobic antibiotics in childhood and IBD
3. Study design and population
- Study design
- Cohort study – Retrospective cohort (THIN)
- Population
UK children
- Country
UK
- Period
1994-2009
- Sample size
1,072,426 (748 IBD)
4. Methods and endpoints
- Exposure / intervention
Antianaerobic antibiotics
- Comparator
Unexposed
- Endpoints
IBD
- Statistical methods
Adjusted HR
5. Actual results
- Results
Incidence 0.83 vs 1.52/10,000 PY; before age 1 aHR 5.51 (1.66-18.28); each course +6%; >2 courses aHR 4.77.
- Absolute risks
0.83 vs 1.52 per 10,000 person-years.
- Authors' conclusion
Associated with IBD.
6. Strengths
- Very large
- Absolute rates
7. Weaknesses
- Protopathic bias possible
8. Risk of bias
- Orienting tool
- ROBINS-E
- Type of assessment
- simplified assessment (abstract only)
- Full formal assessment
- no
- Overall risk of bias
- some concerns
9. Assessment of the statistical interpretation
Low absolute rates.
10. Relevance to the specific claim
11. Independent contrary findings
12. Transferability to Germany and Europe
High.
13. Overall methodological judgement
Association, low absolute risk.
| Multidimensional assessment | |
|---|---|
| Authenticity of the source | verified |
| Methodological quality | moderate |
| Risk of bias | some concerns |
| Precision of results | moderate |
| Directness | direct |
| Reproducibility | partly replicated |
| Consistency with the overall evidence | consistent |
| Regional transferability | high |
| Adequacy of the interpretation (by the archive) | not applicable |
14. Open questions
15. Linked fact checks
Use by the Tayebat archive
Note: according to the archive, the studies were compiled by the archive operators. Whether Dr. Elawady himself cited this study is not established.
- What the archive says about the study
Bibliography only.
- A. What was actually studied?
Antibiotics and IBD.
- B. What did the authors find?
Association.
- C. What conclusions do the authors themselves draw?
Association.
- D. What does the archive derive from it?
Supports.
- E. Is this derivation scientifically justified?
Justified.
- Adequacy of the interpretation (by the archive)
- not applicable