Cohort studycited by the Tayebat archiveabstract only checked A-ORG-17 standard review

Denmark: heart and lung risks after spleen removal

Risk of cardiovascular events and pulmonary hypertension following splenectomy - a Danish population-based cohort study from 1996-2012.

Overview

Rørholt M et al.. Haematologica 2017 · PMID 28572164 · DOI 10.3324/haematol.2016.157008

Compared with patients with the same diseases, only stroke risk stayed higher; heart attack risk was explained by the underlying disease.

Does the study support the specific claim? Partly · Methodological quality: high

Study explained simply

What did the researchers want to find out?: CV risk
How was the study done?: Cohort with disease-matched controls
How many people, animals or samples were studied?: ~70,000
What was actually found?: Stroke HR 1.56
How large was the observed effect?: HR 1.56
What do the results mean in everyday life?: Some but not all risks are due to the operation
What are the study's limitations?: 5 years
What does it say about Elawady's specific claim?: Limits claim
Do the results apply to Germany and Europe?: European
What can explicitly not be concluded from this study?: Long-term

Authors: Rørholt M, Ghanima W, Farkas DK, Nørgaard M
Journal: Haematologica
Year: 2017
Identifier: PMID 28572164 DOI 10.3324/haematol.2016.157008 · PMC5541868
Verification: verified (PMID in archive was wrong, corrected) – PubMed E-utilities efetch, 2026-10-25
Retracted: no
Corrections: none
Extent checked: abstract only
Conflicts of interest and funding: COI: not stated in record | Grants: none listed

CV events and pulmonary hypertension after splenectomy

Study design: Cohort study – Population-based cohort with general-population and disease-matched comparison cohorts
Population: Danish splenectomized patients
Country: Denmark
Period: 1996-2012
Sample size: 5306 splenectomized; 53,060 population; 11,651 disease-matched

Results: vs population: MI HR 1.24 (1.01-1.52); PH HR 3.25; stroke HR 2.04. vs disease-matched: only stroke elevated HR 1.56 (1.26-1.92). Underlying diseases explained MI and PH risk.
Absolute risks: not reported
Authors' conclusion: Splenectomized patients at increased stroke risk; underlying diseases explained increased MI and PH.

European.

Methodologically strongest splenectomy study in the bibliography; limits archive claim.

Multidimensional assessment
Multidimensional assessment
Authenticity of the source	verified (PMID in archive was wrong, corrected)
Methodological quality	high
Risk of bias	low
Precision of results	moderate
Directness	direct
Reproducibility	unknown
Consistency with the overall evidence	consistent
Regional transferability	high
Adequacy of the interpretation (by the archive)	not applicable

Note: according to the archive, the studies were compiled by the archive operators. Whether Dr. Elawady himself cited this study is not established.

What the archive says about the study: Listed in the archive bibliography only; the archive gives no specific interpretation.
A. What was actually studied?: CV risk after splenectomy
B. What did the authors find?: Stroke only after disease-matching
C. What conclusions do the authors themselves draw?: Underlying disease explains MI/PH
D. What does the archive derive from it?: Not used in narrative.
E. Is this derivation scientifically justified?: This archive-cited study shows that part of the splenectomy 'risk' is due to underlying disease; the narrative omits this. Archive PMID was wrong (pointed to a moyamoya case report); corrected in register.
Adequacy of the interpretation (by the archive): not applicable