Potentially true Certainty of evidence: low provisional C-ORG-13

Splenectomy raises the risk of venous thrombosis, cardiovascular events and cancer well beyond the first decade after surgery.

Conclusion: Some risks plausible (stroke, clots); cancer and heart risk partly due to underlying disease.

Original statement

أظهر كريستينسون (8,149 من المحاربين، متابعة 27 عاماً) ارتفاعاً مستمراً في الالتهاب الرئوي والإنتان والجلطات والأورام يمتد لما بعد العقد الأول من العملية.

verbatim according to source. Translation by the project; the Arabic wording is authoritative.

Translation

Splenectomy raises the risk of venous thrombosis, cardiovascular events and cancer well beyond the first decade after surgery.

Origin

Source status
Archive editors
Attribution
Archive editors (eltayebat.com); not necessarily Elawady's own words
Origin
https://eltayebat.com/rule/unnecessary-organ-removal/
Attribution uncertainty
Editorial summary/narrative and study selection written by the archive operators; the archive states that the cited research documents harm independently of Dr. Diaa's words.
Claimed mechanism

Loss of spleen.

Claimed health effect

Thrombosis, CVD, cancer.

Population concerned

Splenectomized patients

Geographic restriction by Elawady

not applicable

Scientific assessment

Potentially true – Some evidence points in favour of the statement, but it is not sufficient for a clear judgement.

Certainty of evidence: low – Further research is likely to change the assessment considerably.

1. What was claimed?

Splenectomy raises VTE, CV and cancer risk.

2. What is demonstrably correct?

DVT/PE RR 2.2; certain solid and haematologic cancers RR 1.3-6.0 (A-ORG-16); stroke risk elevated even vs disease-matched patients (HR 1.56, A-ORG-17).

3. What is wrong or exaggerated?

When compared with patients who had the same underlying diseases, the excess myocardial infarction and pulmonary hypertension risk disappeared (A-ORG-17); haematologic cancers after splenectomy may reflect the conditions that led to the operation. The archive presents all risks as consequences of splenectomy.

4. What remains unclear?

Which risks are causal.

5. Which studies support it?

A-ORG-16, A-ORG-17 (stroke).

6. Which studies contradict it?

A-ORG-17 (MI, pulmonary hypertension).

7. What applies to Germany and Europe?

Most cited cohorts are Scandinavian (Denmark, Sweden) and directly European; RCTs from the UK and Finland are directly transferable. Guidelines in Europe also emphasize defined indications (not verified here in detail).

8. What is known about Egypt?

No Egypt-specific data on rates or outcomes of tonsillectomy, cholecystectomy, hysterectomy, splenectomy or thyroid surgery were identified in this review.

9. What practical conclusion is appropriate?

Thromboprophylaxis and surveillance are recommended by study authors; causal cancer risk unclear.

Assessment details

Rationale for certainty of evidence

Associations shown, but confounding by the underlying disease is substantial; a disease-matched comparison (archive-cited) explained part of the CV risk.

Source quality

Correct numbers; the archive omits its own cited Rørholt 2017 finding.

Regional transferability

Danish and US data.

Individual exceptions

n/a

Regional scope of the claim
general (biological/medical)
Last reviewed
25 October 2026 provisional

In plain language

The archive says spleen removal increases blood clots, heart disease and cancer for many years. A US study found such associations, but many people have their spleen removed because of diseases that themselves raise these risks. A Danish study cited by the archive compared patients with the same diseases and found that only stroke risk remained higher.

Studies on this claim

Studies supporting the claim (1)

  • Long-term risks after spleen removal in US veterans

    Kristinsson SY et al.. Haematologica 2014 · PMID 24056815 · DOI 10.3324/haematol.2013.092460
    Cohort studycited by the Tayebat archiveabstract only checked★ key study

    Serious infections were 2-3 times more frequent and blood clots about 2 times more frequent after spleen removal.

    Splenectomy raises the risk of venous thrombosis, cardiovascular events and cancer well beyond the first decade after surgery.

    Does the study support the specific claim? Partly · Methodological quality: moderate · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    Splenectomy risks

    How was the study done?

    Cohort

    How many people, animals or samples were studied?

    8149

    What was actually found?

    Higher infections, clots, cancers

    How large was the observed effect?

    RR 1.9-3.4 infections

    What do the results mean in everyday life?

    Vaccination and prophylaxis are important

    What are the study's limitations?

    Confounding by indication

    What does it say about Elawady's specific claim?

    Supports infection risk; cancer less certain

    Do the results apply to Germany and Europe?

    Applicable

    What can explicitly not be concluded from this study?

    Causation for cancer

    Scientific details →

Studies contradicting or limiting the claim (1)

  • Denmark: heart and lung risks after spleen removal

    Rørholt M et al.. Haematologica 2017 · PMID 28572164 · DOI 10.3324/haematol.2016.157008
    Cohort studycited by the Tayebat archiveabstract only checked

    Compared with patients with the same diseases, only stroke risk stayed higher; heart attack risk was explained by the underlying disease.

    Splenectomy raises the risk of venous thrombosis, cardiovascular events and cancer well beyond the first decade after surgery.

    Does the study support the specific claim? Partly · Methodological quality: high · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    CV risk

    How was the study done?

    Cohort with disease-matched controls

    How many people, animals or samples were studied?

    ~70,000

    What was actually found?

    Stroke HR 1.56

    How large was the observed effect?

    HR 1.56

    What do the results mean in everyday life?

    Some but not all risks are due to the operation

    What are the study's limitations?

    5 years

    What does it say about Elawady's specific claim?

    Limits claim

    Do the results apply to Germany and Europe?

    European

    What can explicitly not be concluded from this study?

    Long-term

    Scientific details →

Studies with mixed or unclear results (0)

No studies in this group.

Regional context

Germany / EU

Most cited cohorts are Scandinavian (Denmark, Sweden) and directly European; RCTs from the UK and Finland are directly transferable. Guidelines in Europe also emphasize defined indications (not verified here in detail).

Egypt

No Egypt-specific data on rates or outcomes of tonsillectomy, cholecystectomy, hysterectomy, splenectomy or thyroid surgery were identified in this review.

What applies in my country?

General scientific assessment

Potentially true Some risks plausible (stroke, clots); cancer and heart risk partly due to underlying disease.

This statement concerns biological or medical relationships. The scientific assessment above applies regardless of the country; country-specific food data do not change it.

References

  1. Long-term risks after splenectomy among 8,149 cancer-free American veterans: a cohort study with up to 27 years follow-up.. Kristinsson SY et al.. Haematologica 2014 · PMID 24056815 · DOI 10.3324/haematol.2013.092460
  2. Risk of cardiovascular events and pulmonary hypertension following splenectomy - a Danish population-based cohort study from 1996-2012.. Rørholt M et al.. Haematologica 2017 · PMID 28572164 · DOI 10.3324/haematol.2016.157008

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