Cohort studyindependent cross-checkabstract checked I-BAR-129 standard review
US veterans: suicidal thoughts and attempts after surgery
Bariatric Surgery and Suicide Risk in Patients With Obesity.
Overview
Hung et al.. Ann Surg 2023 · PMID 36805965 · DOI 10.1097/SLA.0000000000005825
Suicide attempts were about 60% more frequent after bypass or sleeve than in similar veterans without surgery.
Does the study support the specific claim? Yes · Methodological quality: moderate
Plain-language summary
Study explained simply
- What did the researchers want to find out?
Suicidality after RYGB/SG
- How was the study done?
Matched cohort
- How many people, animals or samples were studied?
~38,000
- What was actually found?
Ideation aHR 1.21; attempts aHR 1.62
- How large was the observed effect?
aHR 1.62
- What do the results mean in everyday life?
Screen mental health after surgery
- What are the study's limitations?
Mostly men
- What does it say about Elawady's specific claim?
Supports the claim
- Do the results apply to Germany and Europe?
Moderate
- What can explicitly not be concluded from this study?
Causation
Scientific in-depth review
1. Full reference
- Authors
- Hung et al.
- Journal
- Ann Surg
- Year
- 2023
- Identifier
- PMID 36805965 DOI 10.1097/SLA.0000000000005825
- Verification
- verified – PubMed efetch 2026-10-26 + Crossref API
- Retracted
- no
- Corrections
- none
- Extent checked
- abstract only
- Conflicts of interest and funding
COI statement (PubMed record): M.L.M. reports research grants for the National Institutes of Health (NIH) and Veterans Affairs Health Services Research and Development Service outside of the submitted work, and ownership of Amgen stock due to his spouse’s employment. D.E.A. reports research grants from NIH and PCORI outside of the submitted work. The disclosure list was shortened here; the complete statement is in the original publication.
2. Research question
Are 5-year rates of suicidal ideation and attempts higher after RYGB or sleeve than in matched nonsurgical controls?
3. Study design and population
- Study design
- Cohort study – Retrospective matched cohort (US Veterans Affairs), sequential stratification
- Population
Veterans with severe obesity (78.7% men)
- Country
USA
- Period
FY2000-2016
- Sample size
38,199 (ideation cohort); 38,661 (attempt cohort)
- Inclusion and exclusion criteria
Excluded past-year outcome events
4. Methods and endpoints
- Exposure / intervention
RYGB or LSG
- Comparator
Matched nonsurgical veterans
- Endpoints
Suicidal ideation; suicide attempt
- Statistical methods
Cox regression with robust variance
5. Actual results
- Results
Suicidal ideation aHR 1.21 (1.03-1.41); suicide attempt aHR 1.62 (1.22-2.15). Over 40% treated for depression at baseline.
- Absolute risks
not reported in abstract
- Authors' conclusion
Bariatric surgery appears associated with greater risk of suicidal ideation and attempts; careful monitoring and psychological support needed.
6. Strengths
- Includes sleeve patients
- Matched controls
7. Weaknesses
- Mostly male veterans
- Procedure-specific estimates not in abstract
8. Risk of bias
- Orienting tool
- ROBINS-E
- Type of assessment
- simplified assessment (abstract only)
- Full formal assessment
- no
- Overall risk of bias
- some concerns
- Rationale
Observational; coding of ideation.
9. Assessment of the statistical interpretation
Moderate relative increases.
10. Relevance to the specific claim
Extends the suicide-risk finding to a cohort that includes sleeve gastrectomy.
11. Independent contrary findings
12. Transferability to Germany and Europe
US veterans.
13. Overall methodological judgement
Supports C-BAR-07.
| Multidimensional assessment | |
|---|---|
| Authenticity of the source | verified |
| Methodological quality | moderate |
| Risk of bias | some concerns |
| Precision of results | moderate |
| Directness | direct |
| Reproducibility | replicated |
| Consistency with the overall evidence | consistent |
| Regional transferability | moderate |
| Adequacy of the interpretation (by the archive) | not applicable |
14. Open questions
Sleeve vs bypass difference.
15. Linked fact checks
- Bariatric surgery is followed by documented rises in self-harm, suicide-related deaths and alcohol use disorder. – Studies supporting the claim