Meta-analysisindependent cross-checkabstract only checked★ key study I-EGG-05 in-depth review

Eggs and risk of death: 2.2 million people

Egg Consumption and Risk of All-Cause and Cause-Specific Mortality: A Systematic Review and Dose-Response Meta-analysis of Prospective Studies.

Overview

Mousavi SM et al.. Adv Nutr 2022 · PMID 35396834 · DOI 10.1093/advances/nmac040

Egg intake was not linked to overall or heart deaths; a small link with cancer deaths was found.

Does the study support the specific claim? No · Methodological quality: moderate

Study explained simply

What did the researchers want to find out?: Is egg consumption associated with all-cause and cause-specific mortality?
How was the study done?: Systematic review and dose-response meta-analysis of 33 cohorts
How many people, animals or samples were studied?: 2,216,720 participants; 232,408 deaths; General population
What was actually found?: Highest vs lowest: all-cause RR 1.02 (0.94-1.11); CVD 1.04 (0.87-1.23); CHD 0.98; stroke 0.81 (0.64-1.02); cancer mortality 1.20 (1.04-1.39). Per egg/week: +2% all-cause, +4% cancer, -4% stroke mortality (linear). Certainty low to moderate.
How large was the observed effect?: Random effects
What do the results mean in everyday life?: Up to one egg a day appears compatible with a healthy diet.
What are the study's limitations?: Overlap with other meta-analyses; Heterogeneity
What does it say about Elawady's specific claim?: Mostly contradicts; notes uncertainty.
Do the results apply to Germany and Europe?: High.
What can explicitly not be concluded from this study?: Cannot prove causation of cancer deaths.

Is egg consumption associated with all-cause and cause-specific mortality?

Study design: Meta-analysis – Systematic review and dose-response meta-analysis of 33 cohorts
Population: General population
Country: Multinational
Period: Search to March 2021
Sample size: 2,216,720 participants; 232,408 deaths
Inclusion and exclusion criteria: Prospective cohorts

Results: Highest vs lowest: all-cause RR 1.02 (0.94-1.11); CVD 1.04 (0.87-1.23); CHD 0.98; stroke 0.81 (0.64-1.02); cancer mortality 1.20 (1.04-1.39). Per egg/week: +2% all-cause, +4% cancer, -4% stroke mortality (linear). Certainty low to moderate.
Absolute risks: not reported
Authors' conclusion: Eggs can be consumed in low to moderate amounts (<=1 egg/day) as part of a healthy diet.

Linear +2% per egg/week vs null highest-lowest: inconsistent small signal.

Cancer mortality signal.

High.

No mortality harm overall; cancer mortality signal uncertain.

Multidimensional assessment
Multidimensional assessment
Authenticity of the source	verified
Methodological quality	moderate
Risk of bias	some concerns
Precision of results	moderate
Directness	direct
Reproducibility	replicated
Consistency with the overall evidence	mixed
Regional transferability	high
Adequacy of the interpretation (by the archive)	not applicable

Cancer mortality.