Randomised controlled trialindependent cross-checkabstract checked I-EGG-106 standard review

An egg a day did not change growth in Malawian babies

The effect of eggs on early child growth in rural Malawi: the Mazira Project randomized controlled trial.

Overview

Stewart CP et al.. Am J Clin Nutr 2019 · PMID 31386106 · DOI 10.1093/ajcn/nqz163

No overall effect on length or weight after 6 months.

Does the study support the specific claim? Unclear · Methodological quality: high

Original publication

Plain-language summary

Study explained simply
What did the researchers want to find out?

Test eggs for growth.

How was the study done?

Randomized trial.

How many people, animals or samples were studied?

660 infants.

What was actually found?

No effect on growth overall.

How large was the observed effect?

Head circumference z +0.18.

What do the results mean in everyday life?

Eggs are not a magic growth food, but nothing suggests they harmed the children.

What are the study's limitations?

Low stunting at baseline.

What does it say about Elawady's specific claim?

Neither supports nor clearly refutes harm; balances the Ecuador result.

Do the results apply to Germany and Europe?

Limited.

What can explicitly not be concluded from this study?

It cannot show that eggs are harmful.

Scientific in-depth review

1. Full reference

Authors
Stewart CP et al.
Journal
Am J Clin Nutr
Year
2019
Identifier
PMID 31386106 DOI 10.1093/ajcn/nqz163
Verification
verified – PubMed efetch 2026-10-26; Crossref works API 2026-10-26
Retracted
no
Corrections
none
Extent checked
abstract only
Conflicts of interest and funding

NIDDK/NIH and non-US government support (PubMed).

2. Research question

Does one egg per day improve growth of children aged 6-9 months in rural Malawi?

3. Study design and population

Study design
Randomised controlled trial – Individually randomized controlled trial with blinded outcome assessment, 6 months
Population

Children aged 6-9 months, rural Malawi

Country

Malawi

Period

Randomization February-July 2018

Sample size

660 (331 egg, 329 control); 10% loss to follow-up

Inclusion and exclusion criteria

not detailed in abstract

4. Methods and endpoints

Exposure / intervention

1 egg per day for 6 months

Comparator

Control with equal visit frequency

Endpoints

Length-for-age, weight-for-age, weight-for-length, head circumference z scores

Statistical methods

Intention-to-treat comparisons

5. Actual results

Results

No intervention effect on length-for-age, weight-for-age or weight-for-length z scores; head circumference-for-age z +0.18 (0.01-0.34); effect on length only among children of mothers with higher education (interaction P = 0.024). Egg consumption rose to 84.5% (3 months) and 70.3% (6 months) in the intervention group.

Absolute risks

not reported

Authors' conclusion

Providing 1 egg per day had no overall effect on linear growth; a background diet rich in animal source foods and low stunting may have limited the impact.

6. Strengths

  • Larger trial; blinded assessors
  • Registered (NCT03385252)

7. Weaknesses

  • Low baseline stunting
  • Adherence declined

8. Risk of bias

Orienting tool
RoB 2
Type of assessment
simplified assessment (abstract only)
Full formal assessment
no
Overall risk of bias
low
Rationale

Blinded outcome assessment; simplified judgement.

9. Assessment of the statistical interpretation

Null primary results with adequate power; head circumference effect small and secondary.

10. Relevance to the specific claim

Provides balance: eggs did not improve growth in this setting, so benefits should not be overstated. The abstract does not report harms.

11. Independent contrary findings

Ecuador trial positive (I-EGG-105).

12. Transferability to Germany and Europe

Low-income setting.

13. Overall methodological judgement

Shows that the growth benefit of eggs is context-dependent; does not indicate harm.

Multidimensional assessment
Multidimensional assessment
Authenticity of the sourceverified
Methodological qualityhigh
Risk of biaslow
Precision of resultsmoderate
Directnessindirect
Reproducibilitynot replicated
Consistency with the overall evidenceinconsistent
Regional transferabilitymoderate
Adequacy of the interpretation (by the archive)not applicable

14. Open questions

Adverse events not reported in abstract.

15. Linked fact checks