Guideline / position statementindependent cross-checkabstract only checked★ key study I-INTA-09 in-depth review

What should cancer patients eat?

ESPEN guidelines on nutrition in cancer patients.

Overview

Arends J et al.. Clinical nutrition (Edinburgh, Scotland) 2017 · PMID 27637832 · DOI 10.1016/j.clnu.2016.07.015

European guidelines say cancer patients should be screened for malnutrition and should get enough energy and protein.

Does the study support the specific claim? No · Methodological quality: high

Original publication

Plain-language summary

Study explained simply
What did the researchers want to find out?

Nutrition in cancer

How was the study done?

Clinical guideline (GRADE)

How many people, animals or samples were studied?

Adult cancer patients

What was actually found?

Malnutrition worsens outcomes; energy needs should be met

How large was the observed effect?

Not applicable

What do the results mean in everyday life?

Deliberately eating less is risky for many cancer patients

What are the study's limitations?

Abstract only

What does it say about Elawady's specific claim?

Contradicts fasting as a general cancer treatment

Do the results apply to Germany and Europe?

High

What can explicitly not be concluded from this study?

Effects of short supervised fasting

Scientific in-depth review

1. Full reference

Authors
Arends J et al.
Journal
Clinical nutrition (Edinburgh, Scotland)
Year
2017
Identifier
PMID 27637832 DOI 10.1016/j.clnu.2016.07.015
Verification
verified – PubMed efetch 2026-10-25
Retracted
no
Corrections
none
Extent checked
abstract only
Conflicts of interest and funding

Commissioned and financially supported by ESPEN and the European Partnership for Action Against Cancer (EPAAC)

2. Research question

Nutritional management of adult cancer patients

3. Study design and population

Study design
Guideline / position statement – Evidence-based clinical practice guideline (GRADE)
Population

Adult cancer patients

Country

Europe (ESPEN/EPAAC)

Period

Published 2017

Sample size

Not applicable

Inclusion and exclusion criteria

Meta-analyses, systematic reviews and comparative studies by PICO questions

4. Methods and endpoints

Exposure / intervention

Nutritional interventions

Comparator

Not applicable

Endpoints

Malnutrition, clinical outcome

Statistical methods

GRADE

5. Actual results

Results

Malnutrition and loss of muscle mass are frequent in cancer patients and have a negative effect on clinical outcome. All cancer patients should be screened regularly for malnutrition. In all patients, except at end of life, energy and substrate requirements should be met through step-wise nutritional interventions.

Absolute risks

Not applicable

Authors' conclusion

Nutritional care should be integrated into cancer care and accompanied by exercise training.

6. Strengths

  • GRADE-based
  • Multi-professional

7. Weaknesses

  • Abstract only read
  • Evidence gaps acknowledged

8. Risk of bias

Orienting tool
none applicable
Type of assessment
simplified assessment (abstract only)
Full formal assessment
no
Overall risk of bias
low
Rationale

Guideline; not formally appraised (AGREE II not applied).

9. Assessment of the statistical interpretation

Recommendation-level evidence.

10. Relevance to the specific claim

Meeting energy needs is the standard; prolonged alternate-day fasting and reducing solid food risk malnutrition in cancer patients.

11. Independent contrary findings

Short supervised fasting around chemotherapy is being studied (I-INTA-08).

12. Transferability to Germany and Europe

High.

13. Overall methodological judgement

Authoritative standard of care for nutrition in cancer.

Multidimensional assessment
Multidimensional assessment
Authenticity of the sourceverified
Methodological qualityhigh
Risk of biaslow
Precision of resultsnot applicable
Directnessdirect
Reproducibilityreplicated
Consistency with the overall evidenceconsistent
Regional transferabilityhigh
Adequacy of the interpretation (by the archive)not applicable

14. Open questions

Role of short-term fasting as adjunct.

15. Linked fact checks