Guideline / position statementindependent cross-checkabstract only checked★ key study I-INTA-09 in-depth review
What should cancer patients eat?
ESPEN guidelines on nutrition in cancer patients.
Overview
Arends J et al.. Clinical nutrition (Edinburgh, Scotland) 2017 · PMID 27637832 · DOI 10.1016/j.clnu.2016.07.015
European guidelines say cancer patients should be screened for malnutrition and should get enough energy and protein.
Does the study support the specific claim? No · Methodological quality: high
Plain-language summary
Study explained simply
- What did the researchers want to find out?
Nutrition in cancer
- How was the study done?
Clinical guideline (GRADE)
- How many people, animals or samples were studied?
Adult cancer patients
- What was actually found?
Malnutrition worsens outcomes; energy needs should be met
- How large was the observed effect?
Not applicable
- What do the results mean in everyday life?
Deliberately eating less is risky for many cancer patients
- What are the study's limitations?
Abstract only
- What does it say about Elawady's specific claim?
Contradicts fasting as a general cancer treatment
- Do the results apply to Germany and Europe?
High
- What can explicitly not be concluded from this study?
Effects of short supervised fasting
Scientific in-depth review
1. Full reference
- Authors
- Arends J et al.
- Journal
- Clinical nutrition (Edinburgh, Scotland)
- Year
- 2017
- Identifier
- PMID 27637832 DOI 10.1016/j.clnu.2016.07.015
- Verification
- verified – PubMed efetch 2026-10-25
- Retracted
- no
- Corrections
- none
- Extent checked
- abstract only
- Conflicts of interest and funding
Commissioned and financially supported by ESPEN and the European Partnership for Action Against Cancer (EPAAC)
2. Research question
Nutritional management of adult cancer patients
3. Study design and population
- Study design
- Guideline / position statement – Evidence-based clinical practice guideline (GRADE)
- Population
Adult cancer patients
- Country
Europe (ESPEN/EPAAC)
- Period
Published 2017
- Sample size
Not applicable
- Inclusion and exclusion criteria
Meta-analyses, systematic reviews and comparative studies by PICO questions
4. Methods and endpoints
- Exposure / intervention
Nutritional interventions
- Comparator
Not applicable
- Endpoints
Malnutrition, clinical outcome
- Statistical methods
GRADE
5. Actual results
- Results
Malnutrition and loss of muscle mass are frequent in cancer patients and have a negative effect on clinical outcome. All cancer patients should be screened regularly for malnutrition. In all patients, except at end of life, energy and substrate requirements should be met through step-wise nutritional interventions.
- Absolute risks
Not applicable
- Authors' conclusion
Nutritional care should be integrated into cancer care and accompanied by exercise training.
6. Strengths
- GRADE-based
- Multi-professional
7. Weaknesses
- Abstract only read
- Evidence gaps acknowledged
8. Risk of bias
- Orienting tool
- none applicable
- Type of assessment
- simplified assessment (abstract only)
- Full formal assessment
- no
- Overall risk of bias
- low
- Rationale
Guideline; not formally appraised (AGREE II not applied).
9. Assessment of the statistical interpretation
Recommendation-level evidence.
10. Relevance to the specific claim
Meeting energy needs is the standard; prolonged alternate-day fasting and reducing solid food risk malnutrition in cancer patients.
11. Independent contrary findings
Short supervised fasting around chemotherapy is being studied (I-INTA-08).
12. Transferability to Germany and Europe
High.
13. Overall methodological judgement
Authoritative standard of care for nutrition in cancer.
| Multidimensional assessment | |
|---|---|
| Authenticity of the source | verified |
| Methodological quality | high |
| Risk of bias | low |
| Precision of results | not applicable |
| Directness | direct |
| Reproducibility | replicated |
| Consistency with the overall evidence | consistent |
| Regional transferability | high |
| Adequacy of the interpretation (by the archive) | not applicable |
14. Open questions
Role of short-term fasting as adjunct.
15. Linked fact checks
- In his practice he treats cancer with fasting (fasting every other day) and by reducing solid foods; he himself can go for days without food, on sugar-cane juice only. – Studies contradicting or limiting the claim