Cross-sectional studyindependent cross-checkabstract only checked I-LEG-06 standard review
G6PD deficiency in jaundiced Egyptian newborns
Prevalence of glucose-6-phosphate dehydrogenase deficiency in jaundiced Egyptian neonates.
Overview
Abo El Fotoh WM et al.. J Matern Fetal Neonatal Med 2016 · PMID 26866975 · DOI 10.3109/14767058.2016.1148133
About 9% of jaundiced newborns had G6PD deficiency.
Does the study support the specific claim? Partly · Methodological quality: low
Plain-language summary
Study explained simply
- What did the researchers want to find out?
Frequency in jaundiced neonates
- How was the study done?
Cross-sectional
- How many people, animals or samples were studied?
202
- What was actually found?
8.9% deficient
- How large was the observed effect?
Not applicable
- What do the results mean in everyday life?
Relevant for Egypt.
- What are the study's limitations?
Selected sample
- What does it say about Elawady's specific claim?
Context only
- Do the results apply to Germany and Europe?
High (Egypt)
- What can explicitly not be concluded from this study?
Cannot give general prevalence.
Scientific in-depth review
1. Full reference
- Authors
- Abo El Fotoh WM et al.
- Journal
- J Matern Fetal Neonatal Med
- Year
- 2016
- Identifier
- PMID 26866975 DOI 10.3109/14767058.2016.1148133
- Verification
- verified – PubMed efetch 2026-10-25
- Retracted
- no
- Corrections
- none
- Extent checked
- abstract only
- Conflicts of interest and funding
not stated in abstract
2. Research question
Frequency of G6PD deficiency in neonatal hyperbilirubinaemia.
3. Study design and population
- Study design
- Cross-sectional study – Cross-sectional study in jaundiced neonates
- Population
Neonates with indirect hyperbilirubinaemia
- Country
Egypt
- Period
Not stated
- Sample size
202
- Inclusion and exclusion criteria
Term/preterm babies up to 13 days with jaundice
4. Methods and endpoints
- Exposure / intervention
Not applicable
- Comparator
Not applicable
- Endpoints
G6PD activity
- Statistical methods
Descriptive
5. Actual results
- Results
18 of 202 (8.9%) G6PD-deficient, all males.
- Absolute risks
not reported
- Authors' conclusion
G6PD deficiency is an important cause of neonatal jaundice from day 2.
6. Strengths
- Enzyme assay
7. Weaknesses
- Selected (jaundiced) sample; not population prevalence
8. Risk of bias
- Orienting tool
- none applicable
- Type of assessment
- simplified assessment (abstract only)
- Full formal assessment
- no
- Overall risk of bias
- some concerns
- Rationale
Selection.
9. Assessment of the statistical interpretation
Not population prevalence.
10. Relevance to the specific claim
Egyptian prevalence context (C-LEG-03).
11. Independent contrary findings
None.
12. Transferability to Germany and Europe
Egypt-specific.
13. Overall methodological judgement
Indicative only.
| Multidimensional assessment | |
|---|---|
| Authenticity of the source | verified |
| Methodological quality | low |
| Risk of bias | some concerns |
| Precision of results | low |
| Directness | indirect |
| Reproducibility | partly replicated |
| Consistency with the overall evidence | unknown |
| Regional transferability | high |
| Adequacy of the interpretation (by the archive) | not applicable |
14. Open questions
Population prevalence.