Cross-sectional studycited by the Tayebat archiveabstract only checked A-CHK-16 standard review

Poultry intake and arsenic in US urine

Poultry Consumption and Arsenic Exposure in the U.S. Population.

Overview

Nigra AE et al.. Environ Health Perspect 2017 · PMID 27735790 · DOI 10.1289/EHP351

Heavy poultry eaters had about 12% higher urine arsenic.

Does the study support the specific claim? Yes · Methodological quality: moderate

Original publication

Plain-language summary

Study explained simply
What did the researchers want to find out?

Is poultry intake associated with urinary arsenic in the US population?

How was the study done?

Cross-sectional analysis of NHANES 2003-2010 (24-h recall and urine arsenic)

How many people, animals or samples were studied?

3,329 participants; US participants >=6 years with undetectable arsenobetaine

What was actually found?

Highest quartile: total arsenic GMR 1.12 (1.04-1.22), DMA 1.13 (1.06-1.20). Turkey fall/winter: 1.17 (0.99-1.39), p-trend 0.02.

How large was the observed effect?

Geometric mean ratios

What do the results mean in everyday life?

A historical US exposure route.

What are the study's limitations?

Single 24-h recall; Cross-sectional

What does it say about Elawady's specific claim?

Supports.

Do the results apply to Germany and Europe?

Low.

What can explicitly not be concluded from this study?

Cannot show disease.

Scientific in-depth review

1. Full reference

Authors
Nigra AE, Nachman KE, Love DC, Grau-Perez M, Navas-Acien A
Journal
Environ Health Perspect
Year
2017
Identifier
PMID 27735790 DOI 10.1289/EHP351 · PMC5332189
Verification
verified – PubMed E-utilities efetch, 2026-10-25
Retracted
no
Corrections
none
Extent checked
abstract only
Conflicts of interest and funding

Authors declare no competing interests; NIEHS

2. Research question

Is poultry intake associated with urinary arsenic in the US population?

3. Study design and population

Study design
Cross-sectional study – Cross-sectional analysis of NHANES 2003-2010 (24-h recall and urine arsenic)
Population

US participants >=6 years with undetectable arsenobetaine

Country

USA

Period

2003-2010

Sample size

3,329 participants

Inclusion and exclusion criteria

Urine arsenic available; arsenobetaine undetectable

4. Methods and endpoints

Exposure / intervention

Poultry intake (24-h recall)

Comparator

Non-consumers

Endpoints

Urine total arsenic, DMA

Statistical methods

Geometric mean ratios

5. Actual results

Results

Highest quartile: total arsenic GMR 1.12 (1.04-1.22), DMA 1.13 (1.06-1.20). Turkey fall/winter: 1.17 (0.99-1.39), p-trend 0.02.

Absolute risks

not applicable

Authors' conclusion

Strong suggestive evidence that historical arsenical drug use contributed to exposure.

6. Strengths

  • National sample

7. Weaknesses

  • Single 24-h recall
  • Cross-sectional

8. Risk of bias

Orienting tool
ROBINS-E
Type of assessment
simplified assessment (abstract only)
Full formal assessment
no
Overall risk of bias
some concerns
Rationale

Exposure misclassification.

9. Assessment of the statistical interpretation

Small (12-13%) differences.

10. Relevance to the specific claim

C-CHK-07.

11. Independent contrary findings

Withdrawal of arsenicals.

12. Transferability to Germany and Europe

Low.

13. Overall methodological judgement

Supports historical claim.

Multidimensional assessment
Multidimensional assessment
Authenticity of the sourceverified
Methodological qualitymoderate
Risk of biassome concerns
Precision of resultsmoderate
Directnessdirect
Reproducibilitypartly replicated
Consistency with the overall evidenceconsistent
Regional transferabilitylow
Adequacy of the interpretation (by the archive)essentially correct but incomplete

14. Open questions

Post-withdrawal levels.

15. Linked fact checks

Use by the Tayebat archive

Note: according to the archive, the studies were compiled by the archive operators. Whether Dr. Elawady himself cited this study is not established.

What the archive says about the study

Listed in bibliography; narrative: NHANES 2017 linked poultry intake to measurably higher urinary arsenic.

A. What was actually studied?

Poultry and urine arsenic.

B. What did the authors find?

12% higher total arsenic.

C. What conclusions do the authors themselves draw?

Historical arsenical use contributed.

D. What does the archive derive from it?

Supports arsenic narrative.

E. Is this derivation scientifically justified?

Essentially correct; effect size small and historical.

Adequacy of the interpretation (by the archive)
essentially correct but incomplete