Cross-sectional studycited by the Tayebat archiveabstract only checked A-CHK-16 standard review
Poultry intake and arsenic in US urine
Poultry Consumption and Arsenic Exposure in the U.S. Population.
Overview
Nigra AE et al.. Environ Health Perspect 2017 · PMID 27735790 · DOI 10.1289/EHP351
Heavy poultry eaters had about 12% higher urine arsenic.
Does the study support the specific claim? Yes · Methodological quality: moderate
Plain-language summary
Study explained simply
- What did the researchers want to find out?
Is poultry intake associated with urinary arsenic in the US population?
- How was the study done?
Cross-sectional analysis of NHANES 2003-2010 (24-h recall and urine arsenic)
- How many people, animals or samples were studied?
3,329 participants; US participants >=6 years with undetectable arsenobetaine
- What was actually found?
Highest quartile: total arsenic GMR 1.12 (1.04-1.22), DMA 1.13 (1.06-1.20). Turkey fall/winter: 1.17 (0.99-1.39), p-trend 0.02.
- How large was the observed effect?
Geometric mean ratios
- What do the results mean in everyday life?
A historical US exposure route.
- What are the study's limitations?
Single 24-h recall; Cross-sectional
- What does it say about Elawady's specific claim?
Supports.
- Do the results apply to Germany and Europe?
Low.
- What can explicitly not be concluded from this study?
Cannot show disease.
Scientific in-depth review
1. Full reference
- Authors
- Nigra AE, Nachman KE, Love DC, Grau-Perez M, Navas-Acien A
- Journal
- Environ Health Perspect
- Year
- 2017
- Identifier
- PMID 27735790 DOI 10.1289/EHP351 · PMC5332189
- Verification
- verified – PubMed E-utilities efetch, 2026-10-25
- Retracted
- no
- Corrections
- none
- Extent checked
- abstract only
- Conflicts of interest and funding
Authors declare no competing interests; NIEHS
2. Research question
Is poultry intake associated with urinary arsenic in the US population?
3. Study design and population
- Study design
- Cross-sectional study – Cross-sectional analysis of NHANES 2003-2010 (24-h recall and urine arsenic)
- Population
US participants >=6 years with undetectable arsenobetaine
- Country
USA
- Period
2003-2010
- Sample size
3,329 participants
- Inclusion and exclusion criteria
Urine arsenic available; arsenobetaine undetectable
4. Methods and endpoints
- Exposure / intervention
Poultry intake (24-h recall)
- Comparator
Non-consumers
- Endpoints
Urine total arsenic, DMA
- Statistical methods
Geometric mean ratios
5. Actual results
- Results
Highest quartile: total arsenic GMR 1.12 (1.04-1.22), DMA 1.13 (1.06-1.20). Turkey fall/winter: 1.17 (0.99-1.39), p-trend 0.02.
- Absolute risks
not applicable
- Authors' conclusion
Strong suggestive evidence that historical arsenical drug use contributed to exposure.
6. Strengths
- National sample
7. Weaknesses
- Single 24-h recall
- Cross-sectional
8. Risk of bias
- Orienting tool
- ROBINS-E
- Type of assessment
- simplified assessment (abstract only)
- Full formal assessment
- no
- Overall risk of bias
- some concerns
- Rationale
Exposure misclassification.
9. Assessment of the statistical interpretation
Small (12-13%) differences.
10. Relevance to the specific claim
11. Independent contrary findings
Withdrawal of arsenicals.
12. Transferability to Germany and Europe
Low.
13. Overall methodological judgement
Supports historical claim.
| Multidimensional assessment | |
|---|---|
| Authenticity of the source | verified |
| Methodological quality | moderate |
| Risk of bias | some concerns |
| Precision of results | moderate |
| Directness | direct |
| Reproducibility | partly replicated |
| Consistency with the overall evidence | consistent |
| Regional transferability | low |
| Adequacy of the interpretation (by the archive) | essentially correct but incomplete |
14. Open questions
Post-withdrawal levels.
15. Linked fact checks
- Chickens were fed arsenical drugs (roxarsone) that raise carcinogenic inorganic arsenic in chicken meat and in consumers. – Studies supporting the claim
Use by the Tayebat archive
Note: according to the archive, the studies were compiled by the archive operators. Whether Dr. Elawady himself cited this study is not established.
- What the archive says about the study
Listed in bibliography; narrative: NHANES 2017 linked poultry intake to measurably higher urinary arsenic.
- A. What was actually studied?
Poultry and urine arsenic.
- B. What did the authors find?
12% higher total arsenic.
- C. What conclusions do the authors themselves draw?
Historical arsenical use contributed.
- D. What does the archive derive from it?
Supports arsenic narrative.
- E. Is this derivation scientifically justified?
Essentially correct; effect size small and historical.
- Adequacy of the interpretation (by the archive)
- essentially correct but incomplete