Cohort studycited by the Tayebat archiveabstract only checked A-ORG-15 standard review
Ovary removal and chronic diseases
Accelerated Accumulation of Multimorbidity After Bilateral Oophorectomy: A Population-Based Cohort Study.
Overview
Rocca WA et al.. Mayo Clin Proc 2016 · PMID 27693001 · DOI 10.1016/j.mayocp.2016.08.002
Women who had both ovaries removed before 46 accumulated chronic diseases faster.
Does the study support the specific claim? Yes · Methodological quality: moderate
Plain-language summary
Study explained simply
- What did the researchers want to find out?
Multimorbidity
- How was the study done?
Cohort
- How many people, animals or samples were studied?
n/a
- What was actually found?
Faster accumulation
- How large was the observed effect?
HR 1.22
- What do the results mean in everyday life?
Possible broad health cost
- What are the study's limitations?
Baseline differences
- What does it say about Elawady's specific claim?
Supports
- Do the results apply to Germany and Europe?
Applicable
- What can explicitly not be concluded from this study?
Causation
Scientific in-depth review
1. Full reference
- Authors
- Rocca WA, Gazzuola-Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Kirkland JL, Stewart EA, Miller VM
- Journal
- Mayo Clin Proc
- Year
- 2016
- Identifier
- PMID 27693001 DOI 10.1016/j.mayocp.2016.08.002 · PMC5097693
- Verification
- verified – PubMed E-utilities efetch, 2026-10-25
- Retracted
- no
- Corrections
- none
- Extent checked
- abstract only
- Conflicts of interest and funding
COI: not stated in record | Grants: NIA NIH HHS
2. Research question
Multimorbidity after bilateral oophorectomy
3. Study design and population
- Study design
- Cohort study – Historical cohort (Rochester Epidemiology Project)
- Population
Premenopausal women with bilateral oophorectomy <50
- Country
USA
- Period
1988-2007; median ~14 y
- Sample size
Not in abstract (matched pairs)
4. Methods and endpoints
5. Actual results
- Results
Women with oophorectomy <46 years: increased depression, hyperlipidemia, arrhythmias, CAD, arthritis, asthma, COPD, osteoporosis; accumulation HR 1.22 (1.14-1.31). Several associations reduced with estrogen therapy.
- Absolute risks
not reported
- Authors' conclusion
Bilateral oophorectomy associated with higher multimorbidity even after adjustment; some reduced with estrogen therapy.
6. Strengths
- Adjusted for baseline conditions
7. Weaknesses
- Higher baseline multimorbidity
8. Risk of bias
- Orienting tool
- ROBINS-E
- Type of assessment
- simplified assessment (abstract only)
- Full formal assessment
- no
- Overall risk of bias
- some concerns
9. Assessment of the statistical interpretation
10. Relevance to the specific claim
Supports C-ORG-09.
11. Independent contrary findings
12. Transferability to Germany and Europe
Applicable.
13. Overall methodological judgement
Supportive.
| Multidimensional assessment | |
|---|---|
| Authenticity of the source | verified |
| Methodological quality | moderate |
| Risk of bias | some concerns |
| Precision of results | moderate |
| Directness | direct |
| Reproducibility | partly replicated |
| Consistency with the overall evidence | consistent |
| Regional transferability | moderate |
| Adequacy of the interpretation (by the archive) | not applicable |
14. Open questions
15. Linked fact checks
- Bilateral oophorectomy at hysterectomy for benign disease increases all-cause mortality, coronary disease and lung cancer — roughly one extra death per nine operations (Parker 2013, Nurses' Health Study). – Studies supporting the claim
- Long-term registry data link removal of tonsils, appendix, gallbladder, uterus, ovaries and spleen to higher rates of respiratory disease, autoimmunity, cardiovascular events, gastrointestinal cancers and dementia; each organ does work the body never fully replaces. – Studies supporting the claim
Use by the Tayebat archive
Note: according to the archive, the studies were compiled by the archive operators. Whether Dr. Elawady himself cited this study is not established.
- What the archive says about the study
Listed in the archive bibliography only; the archive gives no specific interpretation.
- A. What was actually studied?
Multimorbidity
- B. What did the authors find?
HR 1.22
- C. What conclusions do the authors themselves draw?
Associated
- D. What does the archive derive from it?
Supports narrative.
- E. Is this derivation scientifically justified?
Supported as association.
- Adequacy of the interpretation (by the archive)
- not applicable