Cohort studyindependent cross-checkabstract checked I-GRN-114 standard review
In Iran, very high white rice intake was linked to diabetes in one of two cohorts
White rice intake and incidence of type-2 diabetes: analysis of two prospective cohort studies from Iran.
Overview
Golozar A et al.. BMC Public Health 2017 · PMID 28137245 · DOI 10.1186/s12889-016-3999-4
Eating more than 250 g of white rice a day was linked to about twice the odds of diabetes in Tehran, but not in rural Golestan.
Does the study support the specific claim? Partly · Methodological quality: moderate
Plain-language summary
Study explained simply
- What did the researchers want to find out?
Link white rice and diabetes in Iran.
- How was the study done?
Two population cohorts.
- How many people, animals or samples were studied?
11,355 adults.
- What was actually found?
Mixed results.
- How large was the observed effect?
OR 2.1 in Tehran.
- What do the results mean in everyday life?
Large daily rice portions may matter.
- What are the study's limitations?
Few cases, inconsistent.
- What does it say about Elawady's specific claim?
Limits the unrestricted rice allowance.
- Do the results apply to Germany and Europe?
Low-moderate.
- What can explicitly not be concluded from this study?
Cannot prove causation.
Scientific in-depth review
1. Full reference
- Authors
- Golozar A et al.
- Journal
- BMC Public Health
- Year
- 2017
- Identifier
- PMID 28137245 DOI 10.1186/s12889-016-3999-4 · PMC5282785
- Verification
- verified – PubMed efetch 2026-10-26; Crossref works API 2026-10-26
- Retracted
- no
- Corrections
- none
- Extent checked
- abstract only
- Conflicts of interest and funding
WHO and NIH (NIDDK) grants
2. Research question
Is white rice intake associated with incident type 2 diabetes in Iran?
3. Study design and population
- Study design
- Cohort study – Two prospective population cohorts (Golestan, Tehran Lipid and Glucose Study)
- Population
Adults without diabetes or chronic disease at baseline
- Country
Iran
- Period
Baselines 2004-2007
- Sample size
9182 (Golestan) + 2173 (TLGS)
- Inclusion and exclusion criteria
Free of T2D and other chronic diseases
4. Methods and endpoints
- Exposure / intervention
Daily white rice intake (FFQ)
- Comparator
Lower intake
- Endpoints
Incident T2D
- Statistical methods
Multivariable logistic regression (odds ratios)
5. Actual results
- Results
902 new T2D cases in Golestan and 81 in TLGS; cumulative incidence 9.9% and 8.0%. Median rice intake 250 g/day (Tehran) vs 120 g/day (Golestan). No significant association in Golestan; in TLGS >250 vs <250 g/day adjusted OR 2.1 (1.1-3.9).
- Absolute risks
Cumulative T2D incidence 8.0-9.9% (overall)
- Authors' conclusion
Increased likelihood of T2D with high white rice intake in Tehran and no association in Golestan.
6. Strengths
- Middle-Eastern population with rice as staple
- Two cohorts
7. Weaknesses
- Logistic regression of cumulative incidence (OR, not HR)
- Few cases in TLGS (81)
- Inconsistent between cohorts
8. Risk of bias
- Orienting tool
- ROBINS-E
- Type of assessment
- simplified assessment (abstract only)
- Full formal assessment
- no
- Overall risk of bias
- some concerns
- Rationale
Residual confounding; FFQ measurement error.
9. Assessment of the statistical interpretation
OR 2.1 approximates RR 1.9 at 8% baseline risk (stats/C-GRN-05); wide CI and inconsistency.
10. Relevance to the specific claim
Regional evidence that high (not moderate) white rice intake may raise T2D risk; null at lower intake.
11. Independent contrary findings
Golestan null.
12. Transferability to Germany and Europe
Low-moderate; higher rice intake than in Europe.
13. Overall methodological judgement
Mixed, regionally relevant.
| Multidimensional assessment | |
|---|---|
| Authenticity of the source | verified |
| Methodological quality | moderate |
| Risk of bias | some concerns |
| Precision of results | low |
| Directness | direct |
| Reproducibility | partly replicated |
| Consistency with the overall evidence | mixed |
| Regional transferability | high |
| Adequacy of the interpretation (by the archive) | not applicable |
14. Open questions
Egyptian cohort data.
15. Linked fact checks
- Rice in all forms (including white rice) is allowed without restriction; 'rice is sugar' and two spoons of rice a day sustain life. – Studies with mixed or unclear results