Cohort studyindependent cross-checkabstract checked I-GRN-114 standard review

In Iran, very high white rice intake was linked to diabetes in one of two cohorts

White rice intake and incidence of type-2 diabetes: analysis of two prospective cohort studies from Iran.

Overview

Golozar A et al.. BMC Public Health 2017 · PMID 28137245 · DOI 10.1186/s12889-016-3999-4

Eating more than 250 g of white rice a day was linked to about twice the odds of diabetes in Tehran, but not in rural Golestan.

Does the study support the specific claim? Partly · Methodological quality: moderate

Original publication

Plain-language summary

Study explained simply
What did the researchers want to find out?

Link white rice and diabetes in Iran.

How was the study done?

Two population cohorts.

How many people, animals or samples were studied?

11,355 adults.

What was actually found?

Mixed results.

How large was the observed effect?

OR 2.1 in Tehran.

What do the results mean in everyday life?

Large daily rice portions may matter.

What are the study's limitations?

Few cases, inconsistent.

What does it say about Elawady's specific claim?

Limits the unrestricted rice allowance.

Do the results apply to Germany and Europe?

Low-moderate.

What can explicitly not be concluded from this study?

Cannot prove causation.

Scientific in-depth review

1. Full reference

Authors
Golozar A et al.
Journal
BMC Public Health
Year
2017
Identifier
PMID 28137245 DOI 10.1186/s12889-016-3999-4 · PMC5282785
Verification
verified – PubMed efetch 2026-10-26; Crossref works API 2026-10-26
Retracted
no
Corrections
none
Extent checked
abstract only
Conflicts of interest and funding

WHO and NIH (NIDDK) grants

2. Research question

Is white rice intake associated with incident type 2 diabetes in Iran?

3. Study design and population

Study design
Cohort study – Two prospective population cohorts (Golestan, Tehran Lipid and Glucose Study)
Population

Adults without diabetes or chronic disease at baseline

Country

Iran

Period

Baselines 2004-2007

Sample size

9182 (Golestan) + 2173 (TLGS)

Inclusion and exclusion criteria

Free of T2D and other chronic diseases

4. Methods and endpoints

Exposure / intervention

Daily white rice intake (FFQ)

Comparator

Lower intake

Endpoints

Incident T2D

Statistical methods

Multivariable logistic regression (odds ratios)

5. Actual results

Results

902 new T2D cases in Golestan and 81 in TLGS; cumulative incidence 9.9% and 8.0%. Median rice intake 250 g/day (Tehran) vs 120 g/day (Golestan). No significant association in Golestan; in TLGS >250 vs <250 g/day adjusted OR 2.1 (1.1-3.9).

Absolute risks

Cumulative T2D incidence 8.0-9.9% (overall)

Authors' conclusion

Increased likelihood of T2D with high white rice intake in Tehran and no association in Golestan.

6. Strengths

  • Middle-Eastern population with rice as staple
  • Two cohorts

7. Weaknesses

  • Logistic regression of cumulative incidence (OR, not HR)
  • Few cases in TLGS (81)
  • Inconsistent between cohorts

8. Risk of bias

Orienting tool
ROBINS-E
Type of assessment
simplified assessment (abstract only)
Full formal assessment
no
Overall risk of bias
some concerns
Rationale

Residual confounding; FFQ measurement error.

9. Assessment of the statistical interpretation

OR 2.1 approximates RR 1.9 at 8% baseline risk (stats/C-GRN-05); wide CI and inconsistency.

10. Relevance to the specific claim

Regional evidence that high (not moderate) white rice intake may raise T2D risk; null at lower intake.

11. Independent contrary findings

Golestan null.

12. Transferability to Germany and Europe

Low-moderate; higher rice intake than in Europe.

13. Overall methodological judgement

Mixed, regionally relevant.

Multidimensional assessment
Multidimensional assessment
Authenticity of the sourceverified
Methodological qualitymoderate
Risk of biassome concerns
Precision of resultslow
Directnessdirect
Reproducibilitypartly replicated
Consistency with the overall evidencemixed
Regional transferabilityhigh
Adequacy of the interpretation (by the archive)not applicable

14. Open questions

Egyptian cohort data.

15. Linked fact checks