False Certainty of evidence: high provisional C-ODD-06

Glucose-lowering drugs are net harmful and belong among the 'forbidden' items; dapagliflozin (Forxiga) is among the 'dirtiest' drugs and kills the brain; leg amputations happen only to people taking diabetes drugs and insulin.

Safety note: Do not stop prescribed diabetes, heart or kidney medication because of this claim; stopping SGLT2 inhibitors or GLP-1 receptor agonists in people with heart failure, kidney disease or cardiovascular disease removes a proven protection. Discuss concerns with the treating physician.
Conclusion: Several diabetes drugs prolong life in large trials; calling them net harmful is false.

Original statement

الفورسيجا ده من اقذر من اقذر ما يمكن يعني انا ما شفتش ادويه اخذر منه غير الانسولين

verbatim according to source. Translation by the project; the Arabic wording is authoritative.

Translation

Glucose-lowering drugs are net harmful and belong among the 'forbidden' items; dapagliflozin (Forxiga) is among the 'dirtiest' drugs and kills the brain; leg amputations happen only to people taking diabetes drugs and insulin.

Origin

Source status
Video transcript (own words)
Attribution
Elawady (machine transcript)
Video
الغيبوبات السكرية ؟! (Open source)
Published
30 April 2025
Timestamp
0:10:28 (location in the original video’s automatic YouTube caption track; confirms where the words occur, not who speaks)
Attribution uncertainty
Archive transcript (YouTube CC or AI-generated); no timestamps; 'published' is the date listed by the archive and may be the upload date. Live-stream transcripts can contain viewer comments read aloud; the quoted passage was checked in context to be spoken by Elawady.
Claimed mechanism

Drugs block normal metabolism; harm outweighs benefit.

Claimed health effect

Brain damage, amputation, death

Population concerned

People with diabetes

Geographic restriction by Elawady

none found

Diverging source versions

Source status
Video transcript (own words)
Attribution
Elawady (machine transcript)
Video
Dr Diaa Al Awady د ضياء العوضي is live! الموت المفاجيء (Open source)
Published
14 July 2025
Timestamp
not available (transcript has no timings)
Attribution uncertainty
Archive transcript (YouTube CC or AI-generated); no timestamps; 'published' is the date listed by the archive and may be the upload date. Live-stream transcripts can contain viewer comments read aloud; the quoted passage was checked in context to be spoken by Elawady.
Source status
Archive editors
Attribution
Archive editors (not Elawady)
Origin
https://eltayebat.com/rule/oral-diabetes-drugs/
Attribution uncertainty
Editorial narrative and study selection written by the archive operators.

يسمع طب ولا غير اللي هيوطي السكر هيتفشخ اللي هياخد انسولين هيتفشخ اللي هياخد دوا جالفس هيتفشخ اللي هياخد فورسيجا هيتفشخ اللي هياخد مونجارو هيتفشخ اللي هياخداني اسمه ايه اللي شبه المونجارو ده اوزمبيك هيتفشخ خلاص اللي [أصوات

Anyone who lowers blood sugar will be harmed: anyone taking insulin, Galvus (vildagliptin), Forxiga (dapagliflozin), Mounjaro (tirzepatide) or Ozempic (semaglutide) will be badly harmed.

Source status
Video transcript (own words)
Attribution
Elawady (machine transcript)
Video
بدأت قناة "Dr Diaa Al Awady د ضياء العوضي" بثًا مباشرًا ذكري يوم ميلادي 😂😂❤️❤️❤️ (Open source)
Published
26 March 2026
Timestamp
1:16:53 (location in the original video’s automatic YouTube caption track; confirms where the words occur, not who speaks)
Attribution uncertainty
Archive transcript (YouTube CC or AI-generated); no timestamps; 'published' is the date listed by the archive and may be the upload date. Live-stream transcripts can contain viewer comments read aloud; the quoted passage was checked in context to be spoken by Elawady.

لن أوقف أدويتي الموصوفة بسبب هذا الموقع

altayybat requires users to confirm on entry that they will not stop prescribed medicines because of the site.

Source status
Third-party site (unofficial)
Attribution
Third-party site (unofficial; lowest attribution level)
Origin
https://altayybat.com/ar/
Attribution uncertainty
altayybat.com states on its pages that it is educational only and not affiliated with Dr. Diaa Elawady. Lowest attribution level; page fetched 2026-10-25.

المضادات الحيوية وأدوية الضغط والسكري والإنسولين ممنوعة|ويجب استشارة طبيبك الخاص وتحت اشرافه

CONFLICT: mytayibat lists antibiotics, blood-pressure and diabetes drugs and insulin as 'forbidden', adding 'consult your own doctor and under his supervision'.

Source status
Third-party site (unofficial)
Attribution
Third-party site (unofficial; lowest attribution level)
Origin
https://mytayibat.com/forbidden
Attribution uncertainty
mytayibat.com is an unofficial third-party site in the sense that it is neither the eltayebat.com archive nor Elawady's own words. Its footer describes it as 'المنصة الرسمية التعليمية لنظام الطيبات' ('the official educational platform of the Tayebat system'), and its pages refer to it as 'the official platform'. This self-description could not be verified: no evidence was found that the site is authorised by Dr. Diaa Elawady's heirs or by the eltayebat.com archive. By contrast, altayybat.com states that it is not affiliated with Dr. Diaa Elawady. Lowest attribution level; page fetched 2026-10-25. original_ar joins two passages of the page with '|'.

Scientific assessment

False – The statement contradicts the robust evidence.

Certainty of evidence: high – Further research is very unlikely to change the assessment.

1. What was claimed?

Diabetes drugs are net harmful; Forxiga kills the brain; amputations are caused by the drugs.

2. What is demonstrably correct?

All drugs have side effects (see C-ODD-05); canagliflozin was associated with toe/metatarsal amputations in CANVAS (6.3 vs 3.4 per 1,000 patient-years; HR 1.97) (A-ODD-09).

3. What is wrong or exaggerated?

The same CANVAS trial showed a net cardiovascular benefit (HR 0.86), fewer serious adverse events than placebo (104.3 vs 120.0 per 1,000 patient-years), and amputations also in the placebo group (3.4 per 1,000 patient-years), which contradicts both 'net harmful' and 'amputations happen only to people taking diabetes drugs' (A-ODD-09). Dapagliflozin reduced cardiovascular death or worsening heart failure (HR 0.74) and all-cause death (HR 0.83) in DAPA-HF (I-ODD-04) and reduced death (HR 0.69) and kidney endpoints in DAPA-CKD, which was stopped early for efficacy (I-ODD-03). Empagliflozin reduced all-cause death by 32% (I-ODD-02); canagliflozin reduced kidney failure by 32% (I-ODD-05); liraglutide reduced death (HR 0.85) (I-ODD-06); semaglutide reduced major cardiovascular events (HR 0.74) (I-ODD-07). Higher glucose exposure is associated with more amputations and complications without threshold (I-INS-04). No evidence was found that dapagliflozin damages the brain.

4. What remains unclear?

How often the adverse effects of individual drugs occur in Egyptian practice was not reviewed. Whether the amputation signal seen with canagliflozin in CANVAS (A-ODD-09) applies to other drugs of the class was not reviewed here.

5. Which studies support it?

None for the claim as stated. A-ODD-09 documents an amputation signal with one drug but also net benefit and amputations on placebo.

6. Which studies contradict it?

A-ODD-09, I-ODD-01, I-ODD-02, I-ODD-03, I-ODD-04, I-ODD-05, I-ODD-06, I-ODD-07, I-INS-04, I-ODD-17.

7. What applies to Germany and Europe?

European (EASD) and German (DDG) guidance follow the same evidence base as the ADA/EASD consensus: individualised HbA1c targets, insulin as mandatory therapy in type 1 diabetes, and SGLT2 inhibitors/GLP-1 receptor agonists for people with cardiovascular or kidney disease. No country-specific difference changes the assessment.

8. What is known about Egypt?

Egypt has one of the highest diabetes prevalences in the region; the same drug classes and insulins are used. Access barriers and cost may make advice to stop medication attractive, which increases the practical risk of this claim. No Egypt-specific evidence changes the assessment.

9. What practical conclusion is appropriate?

Several diabetes drug classes have proven benefits that outweigh their risks in defined patient groups; decisions should be individual and made with a physician.

Assessment details

Rationale for certainty of evidence

Multiple large, double-blind RCTs show reductions in death, heart failure and kidney failure (empagliflozin, dapagliflozin, canagliflozin, liraglutide, semaglutide) and metformin reduced mortality in UKPDS 34. Amputations are caused mainly by diabetic neuropathy and vascular disease driven by hyperglycaemia, which predates modern drugs.

Source quality

Own words plus archive placement of drugs in the 'forbidden' section.

Regional transferability

Universal.

Individual exceptions

Individual drugs may be unsuitable for individual patients (e.g. SGLT2 in type 1 diabetes or ketosis-prone patients).

Regional scope of the claim
general (biological/medical)
Last reviewed
25 October 2026 provisional

In plain language

The videos call Forxiga one of the dirtiest drugs. Yet large trials with thousands of patients showed that Forxiga and similar drugs reduce deaths, heart failure and kidney failure. Amputations in diabetes are mainly caused by nerve and blood vessel damage from long-term high blood sugar, not by medicines in general.

Studies on this claim

Studies supporting the claim (0)

No studies in this group.

Studies contradicting or limiting the claim (10)

  • Metformin in overweight type 2 diabetes (UKPDS 34)

    UKPDS Group. Lancet 1998 · PMID 9742977
    Randomised controlled trialindependent cross-checkabstract only checked★ key study

    Metformin reduced deaths from any cause by about a third over 10 years.

    Does the study support the specific claim? No · Methodological quality: moderate · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    Intensive control with metformin in overweight type 2 diabetes

    How was the study done?

    RCT within UKPDS (UKPDS 34)

    How many people, animals or samples were studied?

    753 (main comparison); Overweight newly diagnosed type 2 diabetes, mean age 53

    What was actually found?

    Mortality -36%.

    How large was the observed effect?

    RR reduction 36% (9-55)

    What do the results mean in everyday life?

    Metformin is protective.

    What are the study's limitations?

    Small arms; Open-label; Conflicting supplementary result

    What does it say about Elawady's specific claim?

    Contradicts C-ODD-01, C-ODD-06; supports C-INS-11.

    Do the results apply to Germany and Europe?

    UK.

    What can explicitly not be concluded from this study?

    Effects in non-overweight patients.

    Scientific details →

  • Empagliflozin heart trial

    Zinman B et al.. N Engl J Med 2015 · PMID 26378978 · DOI 10.1056/NEJMoa1504720
    Randomised controlled trialindependent cross-checkabstract only checked★ key study

    Deaths fell from 8.3% to 5.7% over about 3 years.

    Does the study support the specific claim? No · Methodological quality: high · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    CV outcomes of empagliflozin in type 2 diabetes at high CV risk

    How was the study done?

    Double-blind placebo-controlled RCT (EMPA-REG OUTCOME)

    How many people, animals or samples were studied?

    7,020; Type 2 diabetes with high CV risk

    What was actually found?

    Primary 10.

    How large was the observed effect?

    HR 0.86; death -32%

    What do the results mean in everyday life?

    This drug class protects heart and/or kidneys in the studied patients.

    What are the study's limitations?

    Industry funded; Selected high-risk population

    What does it say about Elawady's specific claim?

    Contradicts C-ODD-06; context for C-ODD-02, C-ODD-08.

    Do the results apply to Germany and Europe?

    Multinational trial including European sites or directly applicable to EU practice.

    What can explicitly not be concluded from this study?

    Benefit in low-risk people; absence of side effects.

    Scientific details →

  • Dapagliflozin (Forxiga) in kidney disease

    Heerspink HJL et al.. N Engl J Med 2020 · PMID 32970396 · DOI 10.1056/NEJMoa2024816
    Randomised controlled trialindependent cross-checkfull text checked★ key study

    Forxiga reduced kidney failure and deaths; the trial was stopped early because the benefit was clear.

    Does the study support the specific claim? No · Methodological quality: high · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    Dapagliflozin in CKD with/without diabetes

    How was the study done?

    Double-blind placebo-controlled RCT (DAPA-CKD)

    How many people, animals or samples were studied?

    4,304; CKD (eGFR 25-75, albuminuria)

    What was actually found?

    Kidney failure, kidney decline or kidney/heart death: 9.2% with dapagliflozin vs 14.5% with placebo; deaths 4.7% vs 6.8%. Amputations 1.6% vs 1.8%; no ketoacidosis cases with dapagliflozin (2 with placebo).

    How large was the observed effect?

    HR 0.61; death HR 0.69

    What do the results mean in everyday life?

    This drug class protects heart and/or kidneys in the studied patients.

    What are the study's limitations?

    Industry funded; stopped early for benefit (can overstate effect); selected high-risk CKD population; type 1 diabetes excluded; median 2.4 years follow-up.

    What does it say about Elawady's specific claim?

    Contradicts C-ODD-06 (Forxiga 'kills'); context for C-ODD-02.

    Do the results apply to Germany and Europe?

    Multinational trial including European sites or directly applicable to EU practice.

    What can explicitly not be concluded from this study?

    Benefit in low-risk people; absence of side effects.

    Scientific details →

  • Dapagliflozin in heart failure

    McMurray JJV et al.. N Engl J Med 2019 · PMID 31535829 · DOI 10.1056/NEJMoa1911303
    Randomised controlled trialindependent cross-checkabstract only checked★ key study

    Fewer heart failure worsenings and deaths with Forxiga.

    Does the study support the specific claim? No · Methodological quality: high · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    Dapagliflozin in heart failure with reduced EF

    How was the study done?

    Double-blind placebo-controlled RCT (DAPA-HF)

    How many people, animals or samples were studied?

    4,744; HFrEF NYHA II-IV, EF <=40%, with/without diabetes

    What was actually found?

    Primary 16.

    How large was the observed effect?

    HR 0.74; death HR 0.83

    What do the results mean in everyday life?

    This drug class protects heart and/or kidneys in the studied patients.

    What are the study's limitations?

    Industry funded; Selected high-risk population

    What does it say about Elawady's specific claim?

    Contradicts C-ODD-06.

    Do the results apply to Germany and Europe?

    Multinational trial including European sites or directly applicable to EU practice.

    What can explicitly not be concluded from this study?

    Benefit in low-risk people; absence of side effects.

    Scientific details →

  • Canagliflozin in diabetic kidney disease

    Perkovic V et al.. N Engl J Med 2019 · PMID 30990260 · DOI 10.1056/NEJMoa1811744
    Randomised controlled trialindependent cross-checkfull text checked★ key study

    Kidney failure and heart problems fell by about a third; amputations and fractures were not increased, but rare ketoacidosis was more common (11 vs 1 cases).

    Does the study support the specific claim? No · Methodological quality: high · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    Canagliflozin and renal outcomes in type 2 diabetes with nephropathy

    How was the study done?

    Double-blind placebo-controlled RCT (CREDENCE)

    How many people, animals or samples were studied?

    4,401; Type 2 diabetes with albuminuric CKD

    What was actually found?

    Primary kidney/heart outcome 43.2 vs 61.2 per 1000 patient-years (30% lower); amputation 12.3 vs 11.2 per 1000 patient-years (not significant); diabetic ketoacidosis 2.2 vs 0.2 per 1000 patient-years.

    How large was the observed effect?

    HR 0.70

    What do the results mean in everyday life?

    This drug class protects heart and/or kidneys in the studied patients.

    What are the study's limitations?

    Industry funded; stopped early for benefit; selected high-risk population; foot checks added during the trial may have lowered amputation risk; rare harms imprecise.

    What does it say about Elawady's specific claim?

    Contradicts C-ODD-06; limits amputation/fracture signals in C-ODD-05.

    Do the results apply to Germany and Europe?

    Multinational trial including European sites or directly applicable to EU practice.

    What can explicitly not be concluded from this study?

    Benefit in low-risk people; absence of side effects (ketoacidosis was increased); amputation safety in routine care without foot surveillance.

    Scientific details →

  • Liraglutide heart trial

    Marso SP et al.. N Engl J Med 2016 · PMID 27295427 · DOI 10.1056/NEJMoa1603827
    Randomised controlled trialindependent cross-checkfull text checked★ key study

    Fewer heart deaths and deaths overall; pancreatitis not increased, but more gallstone disease and a small, non-significant excess of pancreatic cancer.

    Does the study support the specific claim? No · Methodological quality: high · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    CV outcomes of liraglutide

    How was the study done?

    Double-blind placebo-controlled RCT (LEADER)

    How many people, animals or samples were studied?

    9,340; Type 2 diabetes with high CV risk

    What was actually found?

    Heart attack, stroke or heart death 13.0% vs 14.9%; deaths 8.2% vs 9.6%; acute pancreatitis 18 vs 23 patients; pancreatic cancer 13 vs 5 (not significant); gallstone disease 3.1% vs 1.9%.

    How large was the observed effect?

    HR 0.87; death HR 0.85

    What do the results mean in everyday life?

    This drug class protects heart and/or kidneys in the studied patients.

    What are the study's limitations?

    Industry funded with sponsor co-analysis; high-risk population; safety outcomes not powered and not adjusted for multiple testing; 3.5-5 years follow-up.

    What does it say about Elawady's specific claim?

    Contradicts C-ODD-06; limits C-ODD-04.

    Do the results apply to Germany and Europe?

    Multinational trial including European sites or directly applicable to EU practice.

    What can explicitly not be concluded from this study?

    Benefit in low-risk people; that pancreatic cancer risk is absent or present (too few cases); anything about pancreatic cysts.

    Scientific details →

  • Semaglutide heart safety trial

    Marso SP et al.. N Engl J Med 2016 · PMID 27633186 · DOI 10.1056/NEJMoa1607141
    Randomised controlled trialindependent cross-checkabstract only checked★ key study

    Fewer heart attacks/strokes, but more diabetic eye complications and stomach side effects.

    Does the study support the specific claim? No · Methodological quality: high · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    CV safety of semaglutide

    How was the study done?

    Double-blind placebo-controlled RCT (SUSTAIN-6)

    How many people, animals or samples were studied?

    3,297; Type 2 diabetes, 83% with CVD/CKD

    What was actually found?

    Primary 6.

    How large was the observed effect?

    HR 0.74

    What do the results mean in everyday life?

    This drug class protects heart and/or kidneys in the studied patients.

    What are the study's limitations?

    Industry funded; Selected high-risk population

    What does it say about Elawady's specific claim?

    Contradicts C-ODD-06; GI and retinopathy harms relevant to C-ODD-05.

    Do the results apply to Germany and Europe?

    Multinational trial including European sites or directly applicable to EU practice.

    What can explicitly not be concluded from this study?

    Benefit in low-risk people; absence of side effects.

    Scientific details →

  • How much long-term blood sugar matters (UKPDS 35)

    Stratton IM et al.. BMJ 2000 · PMID 10938048 · DOI 10.1136/bmj.321.7258.405
    Cohort studyindependent cross-checkabstract only checked★ key study

    Each 1% lower HbA1c was linked to 21% fewer diabetes deaths and 37% fewer eye/kidney complications.

    Does the study support the specific claim? No · Methodological quality: moderate · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    Relation of glycaemia over time to complications

    How was the study done?

    Prospective observational analysis within UKPDS (UKPDS 35)

    How many people, animals or samples were studied?

    4,585 (3,642 for RR); UKPDS patients (white, Asian Indian, Afro-Caribbean)

    What was actually found?

    Graded risk with HbA1c, no threshold.

    How large was the observed effect?

    -21% per 1% HbA1c

    What do the results mean in everyday life?

    High sugar damages the body.

    What are the study's limitations?

    Observational

    What does it say about Elawady's specific claim?

    Contradicts C-DIAB-01, C-DIAB-02, C-ODD-06 (hyperglycaemia causes complications incl. amputation).

    Do the results apply to Germany and Europe?

    UK.

    What can explicitly not be concluded from this study?

    That pushing HbA1c to normal is always safe.

    Scientific details →

  • ADA/EASD consensus 2022

    Davies MJ et al.. Diabetes Care 2022 · PMID 36148880 · DOI 10.2337/dci22-0034
    Guideline / position statementindependent cross-checkabstract only checked

    Weight management plus heart- and kidney-protective drugs are central to type 2 diabetes care.

    Does the study support the specific claim? No · Methodological quality: high · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    Management of hyperglycaemia in type 2 diabetes

    How was the study done?

    ADA/EASD consensus report based on systematic examination of publications since 2018

    How many people, animals or samples were studied?

    not applicable; Adults with type 2 diabetes

    What was actually found?

    Cardiorenal protection and weight focus.

    How large was the observed effect?

    not applicable

    What do the results mean in everyday life?

    Guideline direction.

    What are the study's limitations?

    Abstract only read

    What does it say about Elawady's specific claim?

    Contradicts C-ODD-06; supports C-INS-11.

    Do the results apply to Germany and Europe?

    EASD co-authored; directly applicable to EU.

    What can explicitly not be concluded from this study?

    Not applicable.

    Scientific details →

  • Canagliflozin heart and kidney trials (CANVAS)

    Neal B et al.. N Engl J Med 2017 · PMID 28605608 · DOI 10.1056/NEJMoa1611925
    Randomised controlled trialcited by the Tayebat archivefull text checked★ key study

    Fewer heart attacks, strokes and heart deaths (-14%), but more toe/foot amputations.

    Does the study support the specific claim? Partly · Methodological quality: high · Certainty of evidence: see overall assessment of the claim

    Original publication · Scientific details

    Study explained simply
    What did the researchers want to find out?

    CV, renal and safety outcomes of canagliflozin

    How was the study done?

    Integrated analysis of two double-blind RCTs (CANVAS Program)

    How many people, animals or samples were studied?

    10,142; Type 2 diabetes with high CV risk, mean age 63.3

    What was actually found?

    14% fewer heart attacks, strokes or heart deaths; about twice as many amputations (6.3 vs 3.4 per 1,000 patient-years), mostly toes; more fractures and genital infections.

    How large was the observed effect?

    HR 0.86 / 1.97

    What do the results mean in everyday life?

    Both benefits and risks; foot care matters.

    What are the study's limitations?

    Funded and co-analysed by the manufacturer; two trials combined; many secondary results only exploratory.

    What does it say about Elawady's specific claim?

    Supports C-ODD-05 (signal); contradicts C-ODD-06 (benefit).

    Do the results apply to Germany and Europe?

    Multinational/US/UK data; transferable to EU practice.

    What can explicitly not be concluded from this study?

    That SGLT2 inhibitors are net harmful.

    Scientific details →

Studies with mixed or unclear results (0)

No studies in this group.

Regional context

Germany / EU

European (EASD) and German (DDG) guidance follow the same evidence base as the ADA/EASD consensus: individualised HbA1c targets, insulin as mandatory therapy in type 1 diabetes, and SGLT2 inhibitors/GLP-1 receptor agonists for people with cardiovascular or kidney disease. No country-specific difference changes the assessment.

Egypt

Egypt has one of the highest diabetes prevalences in the region; the same drug classes and insulins are used. Access barriers and cost may make advice to stop medication attractive, which increases the practical risk of this claim. No Egypt-specific evidence changes the assessment.

What applies in my country?

General scientific assessment

False Several diabetes drugs prolong life in large trials; calling them net harmful is false.

This statement concerns biological or medical relationships. The scientific assessment above applies regardless of the country; country-specific food data do not change it.

References

  1. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.. UKPDS Group. Lancet 1998 · PMID 9742977
  2. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes.. Zinman B et al.. N Engl J Med 2015 · PMID 26378978 · DOI 10.1056/NEJMoa1504720
  3. Dapagliflozin in Patients with Chronic Kidney Disease.. Heerspink HJL et al.. N Engl J Med 2020 · PMID 32970396 · DOI 10.1056/NEJMoa2024816
  4. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction.. McMurray JJV et al.. N Engl J Med 2019 · PMID 31535829 · DOI 10.1056/NEJMoa1911303
  5. Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy.. Perkovic V et al.. N Engl J Med 2019 · PMID 30990260 · DOI 10.1056/NEJMoa1811744
  6. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes.. Marso SP et al.. N Engl J Med 2016 · PMID 27295427 · DOI 10.1056/NEJMoa1603827
  7. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.. Marso SP et al.. N Engl J Med 2016 · PMID 27633186 · DOI 10.1056/NEJMoa1607141
  8. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study.. Stratton IM et al.. BMJ 2000 · PMID 10938048 · DOI 10.1136/bmj.321.7258.405
  9. Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).. Davies MJ et al.. Diabetes Care 2022 · PMID 36148880 · DOI 10.2337/dci22-0034
  10. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes.. Neal B et al.. N Engl J Med 2017 · PMID 28605608 · DOI 10.1056/NEJMoa1611925

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