绿叶菜中的维生素 K 会扰乱华法林治疗的稳定性（档案网站引用了一篇 Medicine (Baltimore) 上的综述）。
原始表述
无阿拉伯语原文。
译文
绿叶菜中的维生素 K 会扰乱华法林治疗的稳定性（档案网站引用了一篇 Medicine (Baltimore) 上的综述）。
出处
- 来源状态
- 档案网站编辑
- 归属
- Archive editors
- 出处
- https://eltayebat.com/rule/leafy-greens-cucurbits/
- 归属的不确定性
- Archive editorial text and study selection written by the archive operators, not necessarily by Elawady.
- 所声称的机制
Vitamin K antagonises vitamin K antagonists.
- 所声称的健康影响
Unstable INR.
- 涉及人群
Patients on vitamin K antagonists
- Elawady 设定的地域限制
none found
科学评估
可能正确 – 有一些证据支持该说法，但不足以得出明确判断。
证据确定性: 中 – 进一步研究仍可能影响该评估。
1. 说法是什么？
Greens destabilise warfarin therapy.
2. 哪些内容可证实是正确的？
Vitamin K reverses the effect of warfarin and phenprocoumon. Large, sudden changes in the amount of vitamin K-rich greens eaten can shift INR: in a randomized crossover trial, a vitamin K-depleted diet raised INR from 2.6 to 3.3 and an enriched diet lowered it from 3.1 to 2.8 (Franco 2004); a weekly change of about 714 ug of dietary vitamin K changed INR by about one unit (Couris 2006). Health services (NHS, MedlinePlus) state that green leafy vegetables can affect warfarin.
3. 哪些内容是错误或夸大的？
The implied conclusion that greens should be avoided is wrong. A consistent intake of greens does not destabilise therapy; low and erratic vitamin K intake is associated with more unstable control (Dentali 2016), and a steady daily vitamin K supplement improved stability in a double-blind RCT (Sconce 2007). Abruptly stopping greens is itself a change that can raise INR and bleeding risk. The archive's cited review (Violi 2016) concluded that evidence does not support advising dietary restriction and recommended stable habits; the archive reverses this conclusion. Newer anticoagulants (DOACs) are not affected by vitamin K.
4. 哪些内容仍不明确？
How much realistic day-to-day variation in greens changes INR; effects on bleeding and clotting events are not measured in the dietary studies.
5. 哪些研究支持该说法？
Franco 2004 (I-VEG-101); Couris 2006 (I-VEG-102); Schurgers 2004 (I-VEG-103, effect from about 150 ug/day); NHS and MedlinePlus guidance.
6. 哪些研究与该说法相矛盾？
Against avoidance: Sconce 2007 (I-VEG-104); Dentali 2016 (I-VEG-105); Violi 2016 (A-VEG-17); Schurgers 2004 (food-borne vitamin K effects short-lived).
7. 对德国和欧洲而言情况如何？
Phenprocoumon is the main vitamin K antagonist in Germany; similar principle applies.
8. 关于埃及的已知情况是什么？
Not specific.
9. 合理的实际结论是什么？
服用华法林或苯丙香豆素的人可以吃绿叶菜，但应使每周的摄入量大致保持一致；在没有告知抗凝门诊的情况下，不应突然开始或停止大量食用，因为可能需要检查 INR 并调整剂量。
评估详情
- 证据确定性的依据
Vitamin K is the pharmacological antidote of vitamin K antagonists. A randomized crossover feeding trial (Franco 2004, I-VEG-101: INR 2.6 to 3.3 on a vitamin K-depleted diet, 3.1 to 2.8 on an enriched diet), a prospective food-record study (Couris 2006, I-VEG-102: about 714 ug/week change per INR unit) and a dose-response study (Schurgers 2004, I-VEG-103: effect from about 150 ug/day) show that substantial changes in vitamin K intake shift INR. Health-service guidance (NHS 2026; MedlinePlus) agrees and advises consistent intake. The same evidence shows that a stable intake is compatible with stable therapy and that low intake is linked to instability (Sconce 2007 RCT, I-VEG-104; Dentali 2016, I-VEG-105; Violi 2016, A-VEG-17). Studies are small, hence moderate rather than high certainty.
- 来源质量
Archive misrepresents the conclusion of its own source.
- 地区可推广性
Applies to patients on warfarin/phenprocoumon in Germany and Egypt.
- 个体例外情况
Large sudden changes in vitamin K intake can affect INR; stable intake is advised.
- 说法的地域范围
- 未说明
- 最近审核
- 2026年10月26日 初步
科学证据详解
仅在特定条件下成立 – 该说法仅在特定剂量、特定人群、特定制备方式或特定情况下成立。
研究问题: In patients taking vitamin K antagonists (warfarin, phenprocoumon, acenocoumarol), do intake and changes in intake of vitamin K-rich leafy greens destabilise anticoagulation (INR), and does avoidance or consistency improve stability?
研究问题详解 (PECO)
- 人群
- Adults on vitamin K antagonists
- 干预或暴露
- Dietary vitamin K (mainly green leafy vegetables): level and week-to-week change
- 对照
- Stable or lower vitamin K intake
- 地域范围
- universal pharmacology
- 结局指标
- INR level and variability
- time in therapeutic range
- bleeding and thrombosis (rarely reported)
研究结果按作者报告呈现。我们的评估见下文。
哪些证据支持该说法？
Changing vitamin K intake shifts warfarin effect
Randomized crossover feeding trial plus observational cohort in anticoagulated patients.
- 实际结果
- Vitamin K-depleted diet: INR 2.6 -> 3.3 (P = 0.005); vitamin K-enriched diet: INR 3.1 -> 2.8 (P = 0.04); intake independently associated with over- and under-coagulation.
- 方法学质量
- moderate (randomized, objective outcome, but n = 12 and extreme 4-day diets)
- 相关性
- direct: tests dietary vitamin K changes in patients
- 局限
- Very small; short; extreme changes.
Week-to-week vitamin K swings move INR
Couris R et al.. Int J Vitam Nutr Res 2006 · PMID 16941417 · DOI 10.1024/0300-9831.76.2.65 队列研究已核查摘要新增Prospective 5-week food-record study in new warfarin users.
- 实际结果
- Weekly change of 714 ug vitamin K changed INR by 1 unit; r = -0.60 between intake change and INR variability.
- 方法学质量
- moderate-low (prospective but small, 28% drop-out)
- 相关性
- direct
- 局限
- Early titration phase; small.
How much vitamin K changes warfarin effect
Dose-response study in anticoagulated volunteers.
- 实际结果
- Significant INR lowering from 150 ug/day vitamin K1; clinically relevant in 25% at that dose; food vitamin K effects short-lived.
- 方法学质量
- moderate (controlled dose-response)
- 相关性
- indirect: healthy volunteers, supplements
- 局限
- Volunteers; supplements; also limits the claim.
哪些证据不支持该说法？
Steady vitamin K can stabilise warfarin
Double-blind RCT of 150 ug/day vitamin K vs placebo in unstable warfarin patients.
- 实际结果
- Time in range +28% vs +15% (P < .01); stable control 19/35 vs 7/33 (recalculated RR 2.56, 1.24-5.28).
- 方法学质量
- moderate-high (double-blind RCT, small)
- 相关性
- indirect: supplement; shows steady vitamin K improves stability
- 局限
- n = 70; selected patients.
Low vitamin K intake linked to unstable warfarin control
Systematic review of 15 studies (1,838 patients).
- 实际结果
- Lower daily vitamin K intake associated with unstable anticoagulation; supplementation may improve time in range in unstable patients.
- 方法学质量
- low-moderate (narrative SR)
- 相关性
- direct
- 局限
- Overlaps with A-VEG-17.
Vitamin K foods and warfarin
Violi F et al.. Medicine (Baltimore) 2016 · PMID 26962786 · DOI 10.1097/MD.0000000000002895 系统综述全文，含结构化偏倚风险评估Archive-cited systematic review (Violi 2016).
总体证据说明了什么？
基于上述研究的编辑评估——其本身并非研究结果。
哪种观点有更好的证据支持？
Large, sudden changes in vitamin K intake (in either direction) shift INR; a consistent intake of leafy greens is compatible with stable therapy, and low or erratic intake is associated with instability. Avoiding greens is not recommended; consistency and informing the anticoagulation clinic are.
为什么有些研究权重更大
The randomized crossover and dose-response studies are direct but small; the double-blind RCT (Sconce) and the systematic reviews address consistency. Regulatory/health-service statements (NHS, MedlinePlus) agree that greens can affect warfarin and advise consistent intake rather than avoidance. Overlapping reviews (Violi, Dentali) are counted once.
因果关系是否已确立？ 是，已确立 Vitamin K is the pharmacological antidote of VKAs; a dose-dependent effect of vitamin K intake on INR is mechanistically established and shown in controlled studies.
仍存在的不确定性
Size of INR effects from realistic day-to-day variation in greens; effect on clinical events (bleeding, thrombosis) is not measured.
合理的结论
Partly true: vitamin K from leafy greens can change warfarin effect when intake changes substantially. It does not follow that greens must be avoided; abruptly stopping greens is itself a change that can raise INR and bleeding risk. Not relevant to DOACs.
为什么研究结果看起来互相矛盾？
Franco 2004 and Couris 2006 show INR shifts with dietary change, while Schurgers 2004 and Violi 2016 find food-borne vitamin K less potent and evidence for dietary advice weak. They answer different questions: the former test large changes; the latter address whether a stable or moderately varying intake needs restriction. Both are compatible with "keep intake consistent".
这是否取决于国家？
- 一般生物学效应
- Universal pharmacology of vitamin K antagonists.
- 饮食习惯
- Relevant where greens such as molokhia, jarjir (rocket) and parsley are eaten in variable amounts.
- 食品原产地
- Vitamin K content varies by vegetable and preparation, not by country.
- 污染物
- not applicable
- 本国生产条件
- not applicable
- 法律规则
- Drug labels and health services (NHS, NLM) advise consistent intake.
- 实际监测数据
- not applicable
足以改变结论的地区差异没有可靠数据支持。
统计复核
- Relative risk, absolute difference and NNT for achieving stable control (from reported counts 19/35 vs 7/33) – RR 2.56 (95% CI 1.24-5.28); ARR 33.1%; NNT 3 (not reported by authors). 已重新计算
- Convert weekly vitamin K change per INR unit into daily amount – 714 ug/week = ~102 ug/day sustained change per INR unit. 已重新计算
- Relative INR change in crossover arms – Depleted +27%; enriched -10% (direction: removal raises INR). 已重新计算
总体证据的确定性（GRADE，简化版）
- 主要结局
- INR change after substantial change in dietary vitamin K
- 起始等级
- 高（随机试验）
- 降级理由
- imprecision (very small trials)
- indirectness (supplements, healthy volunteers in part)
- 升级理由
- dose-response gradient (Schurgers 2004; Couris 2006)
- 结果
- 中
由单名审查者参照 GRADE 方法进行的简化评估；并非正式的 GRADE 专家组评估。GRADE 评价的是针对某一结局的整体证据，而非单项研究。
已核查的临床指南和官方声明
- NHS (England): Warfarin: medicine used to prevent and treat blood clots (2026) · 原始文献
Talk to your doctor before making big changes to your diet; foods high in vitamin K such as broccoli, spinach and other green leafy vegetables can affect how warfarin works; you can still eat these foods, but talk to your warfarin clinic for advice (page reviewed 24 Feb 2026). - U.S. National Library of Medicine (MedlinePlus): Warfarin: MedlinePlus Drug Information (2026) · 原始文献
Eat a healthy diet; eat consistent amounts of vitamin K-containing food week to week; do not eat large amounts of leafy green vegetables or certain vitamin K-rich oils; talk to your doctor before making any changes to your diet. - NIH Office of Dietary Supplements: Vitamin K - Health Professional Fact Sheet · 原始文献 无法获取；内容未采用
检索策略
本次审查的文献检索记录（检索式采用原数据库语法）。
| 数据库 | 日期 | 检索式 | 检索目标 | 命中数 | 纳入数 |
|---|---|---|---|---|---|
| Europe PMC | 2026年10月26日 | (warfarin OR "vitamin K antagonist") AND ("dietary vitamin K" OR "vitamin K intake" OR "green leafy") AND (INR OR "anticoagulation stability" OR "time in therapeutic range") | 支持性证据 | 554 | |
| Europe PMC | 2026年10月26日 | (warfarin OR acenocoumarol OR phenprocoumon) AND ("vitamin K" diet) AND (randomized OR "randomised" OR trial OR "meta-analysis") | 双向 | 2221 | |
| PubMed | 2026年10月26日 | (warfarin OR "vitamin K antagonist*") AND ("dietary vitamin K" OR "vitamin K intake") AND (INR OR anticoagulation) | 支持性证据 | 120 | |
| Europe PMC | 2026年10月26日 | TITLE:"vitamin K" AND TITLE:(warfarin OR anticoagula* OR acenocoumarol OR INR) AND (diet* OR intake OR vegetable*) | 双向 | 357 | |
| Europe PMC | 2026年10月26日 | JOURNAL:"Cochrane Database Syst Rev" AND "vitamin K" AND warfarin | 双向 | 191 | |
| PubMed | 2026年10月26日 | "vitamin K" AND (warfarin OR "vitamin K antagonist*") AND ("anticoagulation control" OR stability) AND (systematic review[pt] OR meta-analysis[pt] OR randomized controlled trial[pt]) | 双向 | 45 | |
| NHS website (guidance) | 2026年10月26日 | https://www.nhs.uk/medicines/warfarin/ (food section) | 指南 | 1 | |
| MedlinePlus (NLM) | 2026年10月26日 | https://medlineplus.gov/druginfo/meds/a682277.html (dietary instructions) | 指南 | 1 | |
| NIH ODS | 2026年10月26日 | https://ods.od.nih.gov/factsheets/VitaminK-HealthProfessional/ (HTTP 403, not used) | 指南 | 0 |
待解决的问题
Whether structured dietary counselling (consistency) improves clinical outcomes; relevance for Egyptian dishes with very high vitamin K (molokhia).
核查深度如何？
6 项相关研究：1 项核查了全文（其中 1 项进行了结构化偏倚风险评估），5 项基于摘要核查，0 项仅核查了文献信息。 尚未进行由两名独立审查者完成的正式评估，也尚未进行独立的人类专家审核。
最近一次科学审核: 2026年10月26日
评定结论的变更历史
- 2026年10月25日 · 第 1 阶段 · 初始评估: 基本错误 (低)
- 2026年10月26日 · 第 4 阶段（系统证据审查） · 评定结论已更改: 基本错误 (低) → 可能正确 (中)
The previous rating relied mainly on the archive reversing the conclusion of Violi 2016. Primary controlled studies (Franco 2004 crossover; Couris 2006; Schurgers 2004 dose-response) and current health-service guidance (NHS 2026; MedlinePlus) confirm that substantial changes in leafy-green intake alter warfarin effect. The literal claim is therefore partly correct; what is wrong is the implied conclusion that greens should be avoided. The archive's misuse of Violi 2016 remains documented.
新来源: I-VEG-101 I-VEG-102 I-VEG-103 I-VEG-104 I-VEG-105
通俗解释
华法林及类似的抗凝药通过对抗维生素 K 起作用，而绿叶菜中含有维生素 K。如果一个人突然吃得多得多或少得多的绿叶菜，抗凝效果就可能改变，所以档案网站部分是对的。但解决办法不是避免吃绿叶菜：有规律地吃大致相同的量与稳定的治疗是相容的，而突然停吃绿叶菜可能使血液过于稀薄。患者在大幅改变饮食之前，应与医生或抗凝门诊沟通。
与该说法相关的研究
支持该说法的研究 (2)
-
Changing vitamin K intake shifts warfarin effect
Franco V et al.. Am J Med 2004 · PMID 15121490 · DOI 10.1016/j.amjmed.2003.12.036随机对照试验独立交叉核查已核查摘要★ 关键研究In 12 patients, a diet low in vitamin K raised INR from 2.6 to 3.3 within a week, and a vitamin K-rich diet lowered it from 3.1 to 2.8.
Large dietary vitamin K changes shift INR in both directions; abrupt removal raised INR.
该研究是否支持这一具体说法？ 部分支持 · 方法学质量: 中 · 证据确定性：见该说法的总体评估
研究通俗解读
- 研究人员想了解什么？
To test whether dietary vitamin K changes anticoagulation.
- 研究是如何开展的？
Observational follow-up plus a randomized crossover feeding trial.
- 研究了多少人、动物或样本？
39 clinic patients; 12 in the trial.
- 实际发现了什么？
Vitamin K intake was linked to both over- and under-anticoagulation; both diet changes moved INR.
- 观察到的效应有多大？
INR +0.7 (depleted), -0.3 (enriched).
- 研究结果对日常生活意味着什么？
Large sudden changes in greens intake can change how strongly warfarin works.
- 该研究有哪些局限？
Tiny sample, 4-day diets, extreme changes.
- 它对 Elawady 的具体说法说明了什么？
Supports that greens can affect warfarin, but the problem is CHANGE in intake; stopping greens is also a change.
- 研究结果是否适用于德国和欧洲？
Applies to all vitamin K antagonists.
- 从该研究中明确不能得出什么结论？
Cannot show that a stable intake of greens is harmful.
-
Week-to-week vitamin K swings move INR
Couris R et al.. Int J Vitam Nutr Res 2006 · PMID 16941417 · DOI 10.1024/0300-9831.76.2.65队列研究独立交叉核查已核查摘要★ 关键研究A weekly change of about 714 micrograms of vitamin K changed INR by about one unit in 43 new warfarin users.
Quantifies INR change per change in vitamin K intake.
该研究是否支持这一具体说法？ 部分支持 · 方法学质量: 中 · 证据确定性：见该说法的总体评估
研究通俗解读
- 研究人员想了解什么？
Quantify the effect of vitamin K variability on INR.
- 研究是如何开展的？
Daily food records and weekly INR for 5 weeks.
- 研究了多少人、动物或样本？
43 completers.
- 实际发现了什么？
Bigger swings in vitamin K went with bigger swings in INR.
- 观察到的效应有多大？
714 ug/week per 1 INR unit; r = -0.60.
- 研究结果对日常生活意味着什么？
Eating very different amounts of greens from week to week can make INR unstable.
- 该研究有哪些局限？
Small, short, early-treatment phase.
- 它对 Elawady 的具体说法说明了什么？
Supports "changes in greens intake affect warfarin", not "greens must be avoided".
- 研究结果是否适用于德国和欧洲？
Applies to all VKA users.
- 从该研究中明确不能得出什么结论？
Cannot show that consistent greens intake is harmful.
该组中没有被标记为关键研究的研究。
与该说法相矛盾或限制该说法的研究 (3)
-
Vitamin K foods and warfarin
Violi F et al.. Medicine (Baltimore) 2016 · PMID 26962786 · DOI 10.1097/MD.0000000000002895系统综述被 Tayebat 档案网站引用全文，含结构化偏倚风险评估★ 关键研究Review found no good evidence that patients on warfarin should restrict leafy greens; stable intake matters.
该研究是否支持这一具体说法？ 否 · 方法学质量: 低 · 证据确定性：见该说法的总体评估
研究通俗解读
- 研究人员想了解什么？
Assess diet-warfarin interaction
- 研究是如何开展的？
Systematic review
- 研究了多少人、动物或样本？
11 studies
- 实际发现了什么？
Conflicting; no basis for restriction
- 观察到的效应有多大？
Effect possibly >150 µg/day
- 研究结果对日常生活意味着什么？
Keep intake stable.
- 该研究有哪些局限？
Few studies
- 它对 Elawady 的具体说法说明了什么？
Contradicts archive
- 研究结果是否适用于德国和欧洲？
High
- 从该研究中明确不能得出什么结论？
Cannot show greens must be avoided.
-
Steady vitamin K can stabilise warfarin
Sconce E et al.. Blood 2007 · PMID 17110451 · DOI 10.1182/blood-2006-09-049262随机对照试验独立交叉核查已核查摘要★ 关键研究A daily 150 microgram vitamin K supplement more than doubled the share of unstable patients who reached stable control (19 of 35 vs 7 of 33).
Steady vitamin K intake improved INR stability; contradicts "greens destabilise" as a general rule.
该研究是否支持这一具体说法？ 否 · 方法学质量: 中 · 证据确定性：见该说法的总体评估
研究通俗解读
- 研究人员想了解什么？
Test whether low-dose vitamin K stabilises warfarin control.
- 研究是如何开展的？
Double-blind RCT, 6 months.
- 研究了多少人、动物或样本？
70 patients with unstable INR.
- 实际发现了什么？
Vitamin K improved stability and time in range.
- 观察到的效应有多大？
Time in range +28% vs +15%.
- 研究结果对日常生活意味着什么？
A constant intake of vitamin K is not the enemy of warfarin; big swings are.
- 该研究有哪些局限？
Small, supplement not food.
- 它对 Elawady 的具体说法说明了什么？
Contradicts the idea that vitamin K-containing greens in themselves destabilise therapy.
- 研究结果是否适用于德国和欧洲？
Universal.
- 从该研究中明确不能得出什么结论？
Cannot prove that eating more greens has the same effect.
-
Low vitamin K intake linked to unstable warfarin control
Dentali F et al.. Semin Thromb Hemost 2016 · PMID 27232386 · DOI 10.1055/s-0036-1581105系统综述独立交叉核查已核查摘要★ 关键研究A review of 15 studies (1,838 patients) found unstable control more often in people with LOW vitamin K intake.
Low vitamin K intake associated with unstable control.
该研究是否支持这一具体说法？ 否 · 方法学质量: 低 · 证据确定性：见该说法的总体评估
研究通俗解读
- 研究人员想了解什么？
Review vitamin K intake and VKA stability.
- 研究是如何开展的？
Systematic review.
- 研究了多少人、动物或样本？
15 studies, 1,838 patients.
- 实际发现了什么？
Low intake linked to instability; supplements may help unstable patients.
- 观察到的效应有多大？
No pooled estimate.
- 研究结果对日常生活意味着什么？
Avoiding greens does not make warfarin more stable.
- 该研究有哪些局限？
Narrative; overlapping studies.
- 它对 Elawady 的具体说法说明了什么？
Argues against avoidance; supports consistent intake.
- 研究结果是否适用于德国和欧洲？
Universal.
- 从该研究中明确不能得出什么结论？
Cannot give a precise effect size.
该组中没有被标记为关键研究的研究。
结果不一或不明确的研究 (1)
-
How much vitamin K changes warfarin effect
Schurgers LJ et al.. Blood 2004 · PMID 15231565 · DOI 10.1182/blood-2004-04-1525其他独立交叉核查已核查摘要★ 关键研究In anticoagulated volunteers, INR fell significantly only from 150 micrograms of daily vitamin K1 upwards; spinach and broccoli meals had short-lived effects.
INR effect from 150 ug/day; food-borne vitamin K effects short-lived.
该研究是否支持这一具体说法？ 部分支持 · 方法学质量: 中 · 证据确定性：见该说法的总体评估
研究通俗解读
- 研究人员想了解什么？
Find the vitamin K dose that disturbs anticoagulation.
- 研究是如何开展的？
Step-wise supplement doses and test meals.
- 研究了多少人、动物或样本？
Healthy anticoagulated volunteers.
- 实际发现了什么？
Effect began at 150 ug/day; vegetable meals had brief effects.
- 观察到的效应有多大？
Threshold 150 ug/day; clinically relevant in 25%.
- 研究结果对日常生活意味着什么？
Small, irregular servings of greens matter less than often feared.
- 该研究有哪些局限？
Not patients; supplements; size not in abstract.
- 它对 Elawady 的具体说法说明了什么？
Partly supports and partly limits the claim.
- 研究结果是否适用于德国和欧洲？
Universal.
- 从该研究中明确不能得出什么结论？
Cannot quantify risk of bleeding or clotting.
该组中没有被标记为关键研究的研究。
地区背景
德国 / 欧盟
Phenprocoumon is the main vitamin K antagonist in Germany; similar principle applies.
埃及
Not specific.
在我的国家适用什么？
一般科学评估
可能正确 部分正确：绿叶菜摄入量的大幅突然变化可能改变华法林的效果，但稳定摄入是安全的，也不建议回避；档案网站把自己所引来源的结论弄反了。
以下食品安全领域与该说法相关：
- 农药与农药残留
- 污染物（重金属、PFAS、PCB、二噁英、硝酸盐）
- 病原体（沙门氏菌、弯曲杆菌等）
水果与蔬菜
选择一个国家，查看针对该国已核查的信息。
局限：法律规则描述的是允许什么，而不是每一种食品实际含有什么。检测数据来自样本，只有结合其方法细节才有意义。
参考文献
- Role of dietary vitamin K intake in chronic oral anticoagulation: prospective evidence from observational and randomized protocols.. Franco V et al.. Am J Med 2004 · PMID 15121490 · DOI 10.1016/j.amjmed.2003.12.036
- Dietary vitamin K variability affects International Normalized Ratio (INR) coagulation indices.. Couris R et al.. Int J Vitam Nutr Res 2006 · PMID 16941417 · DOI 10.1024/0300-9831.76.2.65
- Interaction Between Dietary Vitamin K Intake and Anticoagulation by Vitamin K Antagonists: Is It Really True?: A Systematic Review.. Violi F et al.. Medicine (Baltimore) 2016 · PMID 26962786 · DOI 10.1097/MD.0000000000002895
- Vitamin K supplementation can improve stability of anticoagulation for patients with unexplained variability in response to warfarin.. Sconce E et al.. Blood 2007 · PMID 17110451 · DOI 10.1182/blood-2006-09-049262
- Effect of Vitamin K Intake on the Stability of Treatment with Vitamin K Antagonists: A Systematic Review of the Literature.. Dentali F et al.. Semin Thromb Hemost 2016 · PMID 27232386 · DOI 10.1055/s-0036-1581105
- Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose-response relationships in healthy subjects.. Schurgers LJ et al.. Blood 2004 · PMID 15231565 · DOI 10.1182/blood-2004-04-1525